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Publications

2021

Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation., M.A. Rivas; C. Meydan; C.R. Chin; M.F. Challman; D. Kim; B. Bhinder; A. Kloetgen; A.D. Viny; M.R. Teater; D.R. McNally; A.S. Doane; W. Béguelin; M.Teresa Cal Fernández; H. Shen; X. Wang; R.L. Levine; Z. Chen; A. Tsirigos; O. Elemento; C.E. Mason; A.M. Melnick, Nat Immunol, 2021 02, 22, 2, p.240-253, (2021) PubMed

Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence., C. Duy; M. Li; M. Teater; C. Meydan; F.E. Garrett-Bakelman; T.C. Lee; C.R. Chin; C. Durmaz; K.C. Kawabata; E. Dhimolea; C.S. Mitsiades; H. Doehner; R.J. D'Andrea; M.W. Becker; E.M. Paietta; C.E. Mason; M. Carroll; A.M. Melnick, Cancer Discov, 2021 06, 11, 6, p.1542-1561, (2021) PubMed

H1 histones control the epigenetic landscape by local chromatin compaction., M.A. Willcockson; S.E. Healton; C.N. Weiss; B.A. Bartholdy; Y. Botbol; L.N. Mishra; D.S. Sidhwani; T.J. Wilson; H.B. Pinto; M.I. Maron; K.A. Skalina; L.Norwood Toro; J. Zhao; C.H. Lee; H. Hou; N. Yusufova; C. Meydan; A. Osunsade; Y. David; E. Cesarman; A.M. Melnick; S. Sidoli; B.A. Garcia; W. Edelmann; F. Macian; A.I. Skoultchi, Nature, 2021 01, 589, 7841, p.293-298, (2021) PubMed

An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities., R. Flümann; T. Rehkämper; P. Nieper; P. Pfeiffer; A. Holzem; S. Klein; S. Bhatia; M. Kochanek; I. Kisis; B.W. Pelzer; H. Ahlert; J. Hauer; Ada Palma Guerreiro; J.A. Ryan; M. Reimann; A. Riabinska; J. Wiederstein; M. Krüger; M. Deckert; J. Altmüller; A.R. Klatt; L.P. Frenzel; L. Pasqualucci; W. Béguelin; A.M. Melnick; S. Sander; M. Montesinos-Rongen; A. Brunn; P. Lohneis; R. Büttner; H. Kashkar; A. Borkhardt; A. Letai; T. Persigehl; M. Peifer; C.A. Schmitt; H.Christian Reinhardt; G. Knittel, Blood Cancer Discov, 2021 01, 2, 1, p.70-91, (2021) PubMed

Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture., N. Yusufova; A. Kloetgen; M. Teater; A. Osunsade; J.M. Camarillo; C.R. Chin; A.S. Doane; B.J. Venters; S. Portillo-Ledesma; J. Conway; J.M. Phillip; O. Elemento; D.W. Scott; W. Béguelin; J.D. Licht; N.L. Kelleher; L.M. Staudt; A.I. Skoultchi; M.C. Keogh; E. Apostolou; C.E. Mason; M. Imielinski; T. Schlick; Y. David; A. Tsirigos; D. Allis; A.A. Soshnev; E. Cesarman; A.M. Melnick, Nature, 2021 01, 589, 7841, p.299-305, (2021) PubMed

2020

The therapeutic landscape for cells engineered with chimeric antigen receptors., M. MacKay; E. Afshinnekoo; J. Rub; C. Hassan; M. Khunte; N. Baskaran; B. Owens; L. Liu; G.J. Roboz; M.L. Guzman; A.M. Melnick; S. Wu; C.E. Mason, Nat Biotechnol, 2020 02, 38, 2, p.233-244, (2020) PubMed

TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate., L. Venturutti; M. Teater; A. Zhai; A. Chadburn; L. Babiker; D. Kim; W. Béguelin; T.C. Lee; Y. Kim; C.R. Chin; W.T. Yewdell; B. Raught; J.M. Phillip; Y. Jiang; L.M. Staudt; M.R. Green; J. Chaudhuri; O. Elemento; P. Farinha; A.P. Weng; M.D. Nissen; C. Steidl; R.D. Morin; D.W. Scott; G.G. Prive; A.M. Melnick, Cell, 2020 07 23, 182, 2, p.297-316.e27, (2020) PubMed

The oncogene BCL6 is up-regulated in glioblastoma in response to DNA damage, and drives survival after therapy., M.S. Fabre; N.M. Stanton; T.L. Slatter; S. Lee; D. Senanayake; R.M.A. Gordon; L. Castro; M.R. Rowe; A. Taha; J.A. Royds; N. Hung; A.M. Melnick; M.J. McConnell, PLoS One, 2020, 15, 4, p.e0231470, (2020) PubMed

Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage., C.S. Chu; J.C. Hellmuth; R. Singh; H.Y. Ying; L. Skrabanek; M.R. Teater; A.S. Doane; O. Elemento; A.M. Melnick; R.G. Roeder, Mol Cell, 2020 12 03, 80, 5, p.845-861.e10, (2020) PubMed

The dangers of déjà vu: memory B cells as the cells of origin of ABC-DLBCLs., L. Venturutti; A.M. Melnick, Blood, 2020 11 12, 136, 20, p.2263-2274, (2020) PubMed