Submitted by jup2017 on November 13, 2017 - 2:51pm
| Title | Differentiation therapy for IDH1/2 mutant malignancies. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Garrett-Bakelman, Francine E., and Melnick Ari M. |
| Journal | Cell Res |
| Volume | 23 |
| Issue | 8 |
| Pagination | 975-7 |
| Date Published | 2013 Aug |
| ISSN | 1748-7838 |
| Abstract | <p>Recently discovered recurrent somatic mutations in the key metabolic enzymes IDH1 and IDH2 produce the aberrant oncometabolite 2-HG and contribute to malignant transformation of hematopoietic and glial cells. Two recent reports in Science describe the first IDH1 and IDH2 mutant-specific small-molecule inhibitors, which induce cell differentiation of myeloid leukemias and malignant gliomas.</p> |
| DOI | 10.1038/cr.2013.73 |
| Alternate Journal | Cell Res |
| PubMed ID | 23732524 |
| PubMed Central ID | PMC3731561 |