TitleDiscovering what makes STAT signaling TYK in T-ALL.
Publication TypeJournal Article
Year of Publication2013
AuthorsFontan, Lorena, and Melnick Ari
JournalCancer Discov
Volume3
Issue5
Pagination494-6
Date Published2013 May
ISSN2159-8290
KeywordsAnimals, Humans, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Proto-Oncogene Proteins c-bcl-2, STAT1 Transcription Factor, TYK2 Kinase
Abstract

<p>RNA interference screening establishes TYK2 dependence in T-cell acute lymphoblastic leukemia (T-ALL), leading to identification of TYK2-activating mutations and increased IL-10 receptor signaling in T-ALL cell lines. Cancer Discov; 3(5); 494-6. ©2013 AACR.</p>

DOI10.1158/2159-8290.CD-13-0123
Alternate JournalCancer Discov
PubMed ID23658297