TitleMechanisms of action of BCL6 during germinal center B cell development.
Publication TypeJournal Article
Year of Publication2015
AuthorsHuang, ChuanXin, and Melnick Ari
JournalSci China Life Sci
Date Published2015 Dec
KeywordsB-Lymphocytes, Cell Lineage, Cell Proliferation, Cell Survival, DNA-Binding Proteins, Gene Expression Regulation, Germinal Center, Humans, Lymphoma, B-Cell, Models, Genetic, Proto-Oncogene Proteins c-bcl-6

<p>The transcriptional repressor B cell lymphoma 6 (BCL6) controls a large transcriptional network that is required for the formation and maintenance of germinal centers (GC). GC B cells represent the normal counterpart of most human B-cell lymphomas, which are often characterized by deregulated BCL6 expression or BCL6-mediated pathways. BCL6 suppresses gene transcription largely through recruitment of its co-repressors through its distinct repression domain. Understanding the precise biological roles of each repression domain in normal and malignant B cells is helpful for development of targeted inhibition of BCL6 functions that is emerging as the basis for design of anti-lymphoma therapies. This review focuses on recent progress in the molecular mechanisms of action of BCL6 in B cells and discusses remaining unresolved questions related to how these mechanisms are linked to normal and malignant B cell development.</p>

Alternate JournalSci China Life Sci
PubMed ID26566802