TitleSpecific peptides for the therapeutic targeting of oncogenes.
Publication TypeJournal Article
Year of Publication2006
AuthorsPrive, Gilbert G., and Melnick Ari
JournalCurr Opin Genet Dev
Volume16
Issue1
Pagination71-7
Date Published2006 Feb
ISSN0959-437X
KeywordsAmino Acid Sequence, Animals, Antineoplastic Agents, Drug Carriers, Drug Design, HSP90 Heat-Shock Proteins, Humans, Models, Molecular, Molecular Sequence Data, Neoplasms, Oncogenes, Peptides
Abstract

<p>Tumors are dependent on oncogenic proteins for their maintenance and survival. The ideal cancer therapy would include drugs that specifically target these proteins. Many such proteins function through interfaces that can be difficult to target effectively with small molecules. However, recent advances in cell-permeable peptide technology, improving cellular penetration and stability, raise the possibility that specific peptide interference of oncogenic proteins could be successfully translated to the clinic. Several active anti-tumor peptides were recently described. For example, a stable peptide inhibitor of the Hsp90 ATP-binding pocket killed a wide range of tumors in vitro and in vivo, and a peptide inhibitor of the BCL6 oncoprotein was active in B-cell lymphomas; both peptides functioned without toxicity to normal tissues.</p>

DOI10.1016/j.gde.2005.12.010
Alternate JournalCurr Opin Genet Dev
PubMed ID16377176
Grant ListR01 CA104348 / CA / NCI NIH HHS / United States