Publications

2015

The H3K27me3 demethylase UTX is a gender-specific tumor suppressor in T-cell acute lymphoblastic leukemia., J. Van der Meulen; V. Sanghvi; K. Mavrakis; K. Durinck; F. Fang; F. Matthijssens; P. Rondou; M. Rosen; T. Pieters; P. Vandenberghe; E. Delabesse; T. Lammens; B. De Moerloose; B. Menten; N. Van Roy; B. Verhasselt; B. Poppe; Y. Benoit; T. Taghon; A.M. Melnick; F. Speleman; H.G. Wendel; P. Van Vlierberghe, Blood, 2015 Jan 01, 125, 1, p.13-21, (2015) PubMed

Transcriptome sequencing reveals thousands of novel long non-coding RNAs in B cell lymphoma., A. Verma; Y. Jiang; W. Du; L. Fairchild; A. Melnick; O. Elemento, Genome Med, 2015 Nov 01, 7, , p.110, (2015) PubMed

A Hyperactive Signalosome in Acute Myeloid Leukemia Drives Addiction to a Tumor-Specific Hsp90 Species., H. Zong; A. Gozman; E. Caldas-Lopes; T. Taldone; E. Sturgill; S. Brennan; S.O. Ochiana; E.M. Gomes-DaGama; S. Sen; A. Rodina; J. Koren; M.W. Becker; C.M. Rudin; A. Melnick; R.L. Levine; G.J. Roboz; S.D. Nimer; G. Chiosis; M.L. Guzman, Cell Rep, 2015 Dec 15, 13, 10, p.2159-73, (2015) PubMed

Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis., A.D. Viny; C.J. Ott; B. Spitzer; M. Rivas; C. Meydan; E. Papalexi; D. Yelin; K. Shank; J. Reyes; A. Chiu; Y. Romin; V. Boyko; S. Thota; J.P. Maciejewski; A. Melnick; J.E. Bradner; R.L. Levine, J Exp Med, 2015 Oct 19, 212, 11, p.1819-32, (2015) PubMed

The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development., A. Ortega-Molina; I.W. Boss; A. Canela; H. Pan; Y. Jiang; C. Zhao; M. Jiang; D. Hu; X. Agirre; I. Niesvizky; J.E. Lee; H.T. Chen; D. Ennishi; D.W. Scott; A. Mottok; C. Hother; S. Liu; X.J. Cao; W. Tam; R. Shaknovich; B.A. Garcia; R.D. Gascoyne; K. Ge; A. Shilatifard; O. Elemento; A. Nussenzweig; A.M. Melnick; H.G. Wendel, Nat Med, 2015 Oct, 21, 10, p.1199-208, (2015) PubMed

Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia., S. Shojaee; R. Caeser; M. Buchner; E. Park; S. Swaminathan; C. Hurtz; H. Geng; L.N. Chan; L. Klemm; W.K. Hofmann; Y.Hua Qiu; N. Zhang; K.R. Coombes; E. Paietta; J. Molkentin; P. Koeffler; C.L. Willman; S.P. Hunger; A. Melnick; S.M. Kornblau; M. Müschen, Cancer Cell, 2015 Jul 13, 28, 1, p.114-28, (2015) PubMed

BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms., K. Hatzi; P. Nance; M.A. Kroenke; M. Bothwell; E.K. Haddad; A. Melnick; S. Crotty, J Exp Med, 2015 Apr 06, 212, 4, p.539-53, (2015) PubMed

2014

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia., R. Rampal; A. Alkalin; J. Madzo; A. Vasanthakumar; E. Pronier; J. Patel; Y. Li; J. Ahn; O. Abdel-Wahab; A. Shih; C. Lu; P.S. Ward; J.J. Tsai; T. Hricik; V. Tosello; J.E. Tallman; X. Zhao; D. Daniels; Q. Dai; L. Ciminio; I. Aifantis; C. He; F. Fuks; M.S. Tallman; A. Ferrando; S. Nimer; E. Paietta; C.B. Thompson; J.D. Licht; C.E. Mason; L.A. Godley; A. Melnick; M.E. Figueroa; R.L. Levine, Cell Rep, 2014 Dec 11, 9, 5, p.1841-1855, (2014) PubMed

Dynamic evolution of clonal epialleles revealed by methclone., S. Li; F. Garrett-Bakelman; A.E. Perl; S.M. Luger; C. Zhang; B.L. To; I.D. Lewis; A.L. Brown; R.J. D'Andrea; E. Ross; R. Levine; M. Carroll; A. Melnick; C.E. Mason, Genome Biol, 2014 Sep 27, 15, 9, p.472, (2014) PubMed

Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer., A. Rodina; T. Taldone; Y. Kang; P.D. Patel; J. Koren; P. Yan; E.M.DaGama Gomes; C. Yang; M.R. Patel; L. Shrestha; S.O. Ochiana; C. Santarossa; R. Maharaj; A. Gozman; M.B. Cox; H. Erdjument-Bromage; R.C. Hendrickson; L. Cerchietti; A. Melnick; M.L. Guzman; G. Chiosis, ACS Chem Biol, 2014 Aug 15, 9, 8, p.1698-705, (2014) PubMed