Publications

2019

An "EZ" Epigenetic Road to Leukemia Stem Cell Metabolic Reprogramming?, M. Li; A.M. Melnick, Cancer Discov, 2019 Sep, 9, 9, p.1158-1160, (2019) PubMed

The Impact of Heterogeneity on Single-Cell Sequencing., S.L. Goldman; M. MacKay; E. Afshinnekoo; A.M. Melnick; S. Wu; C.E. Mason, Front Genet, 2019, 10, , p.8, (2019) PubMed

Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis., K. Hatzi; H. Geng; A.S. Doane; C. Meydan; R. LaRiviere; M. Cardenas; C. Duy; H. Shen; M.Nieves Cal Vidal; T. Baslan; H.P. Mohammad; R.G. Kruger; R. Shaknovich; A.M. Haberman; G. Inghirami; S.W. Lowe; A.M. Melnick, Nat Immunol, 2019 Jan, 20, 1, p.86-96, (2019) PubMed

Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL., A. Pastore; F. Gaiti; S.X. Lu; R.M. Brand; S. Kulm; R. Chaligne; H. Gu; K.Y. Huang; E.K. Stamenova; W. Béguelin; Y. Jiang; R.C. Schulman; K.T. Kim; A. Alonso; J.N. Allan; R.R. Furman; A. Gnirke; C.J. Wu; A.M. Melnick; A. Meissner; B.E. Bernstein; O. Abdel-Wahab; D.A. Landau, Nat Commun, 2019 Apr 23, 10, 1, p.1874, (2019) PubMed

Peptide-based covalent inhibitors of MALT1 paracaspase., J.M. Hatcher; G. Du; L. Fontan; I. Us; Q. Qiao; S. Chennamadhavuni; J. Shao; H. Wu; A. Melnick; N.S. Gray; D.A. Scott, Bioorg Med Chem Lett, 2019 Jun 01, 29, 11, p.1336-1339, (2019) PubMed

Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response., X. Agirre; C. Meydan; Y. Jiang; L. Garate; A.S. Doane; Z. Li; A. Verma; B. Paiva; J.I. Martín-Subero; O. Elemento; C.E. Mason; F. Prosper; A. Melnick, Nat Commun, 2019 Feb 18, 10, 1, p.821, (2019) PubMed

BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection., B. Zhu; R. Zhang; C. Li; L. Jiang; M. Xiang; Z. Ye; H. Kita; A.M. Melnick; A.L. Dent; J. Sun, Proc Natl Acad Sci U S A, 2019 Jun 11, 116, 24, p.11888-11893, (2019) PubMed

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease., K. Paz; R. Flynn; J. Du; J. Qi; L. Luznik; I. Maillard; K.P. MacDonald; G.R. Hill; J.S. Serody; W.J. Murphy; P.T. Sage; A.H. Sharpe; D. Miklos; C.S. Cutler; J. Koreth; J.H. Antin; R.J. Soiffer; J. Ritz; J.E. Bradner; A.M. Melnick; B.R. Blazar, Blood, 2019 Jan 03, 133, 1, p.94-99, (2019) PubMed

2018

AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis., M. Teater; P.M. Dominguez; D. Redmond; Z. Chen; D. Ennishi; D.W. Scott; L. Cimmino; P. Ghione; J. Chaudhuri; R.D. Gascoyne; I. Aifantis; G. Inghirami; O. Elemento; A. Melnick; R. Shaknovich, Nat Commun, 2018 Jan 15, 9, 1, p.222, (2018) PubMed

ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia., T. Maes; C. Mascaró; I. Tirapu; A. Estiarte; F. Ciceri; S. Lunardi; N. Guibourt; A. Perdones; M.M.P. Lufino; T.C.P. Somervaille; D.H. Wiseman; C. Duy; A. Melnick; C. Willekens; A. Ortega; M. Martinell; N. Valls; G. Kurz; M. Fyfe; J.Cesar Castro-Palomino; C. Buesa, Cancer Cell, 2018 Mar 12, 33, 3, p.495-511.e12, (2018) PubMed