Melnick Lab

Publications

2019

BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress., T.M. Fernando; R. Marullo; B.Pera Gresely; J.M. Phillip; S.Ning Yang; G. Lundell-Smith; I. Torregroza; H. Ahn; T. Evans; B. Gyorffy; G.G. Prive; M. Hirano; A.M. Melnick; L. Cerchietti, Cancer Discov, 2019 05, 9, 5, p.662-679, (2019) PubMed

Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML., C. Duy; M. Teater; F.E. Garrett-Bakelman; T.C. Lee; C. Meydan; J.L. Glass; M. Li; J.C. Hellmuth; H.P. Mohammad; K.N. Smitheman; A.H. Shih; O. Abdel-Wahab; M.S. Tallman; M.L. Guzman; D. Muench; L. Grimes; G.J. Roboz; R.G. Kruger; C.L. Creasy; E.M. Paietta; R.L. Levine; M. Carroll; A.M. Melnick, Cancer Discov, 2019 07, 9, 7, p.872-889, (2019) PubMed

PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomas., M. Pascual; M. Mena-Varas; E.Francisco Robles; M.J. Garcia-Barchino; C. Panizo; S. Hervas-Stubbs; D. Alignani; A. Sagardoy; J.Ignacio Martinez-Ferrandis; K.L. Bunting; S. Meier; X. Sagaert; D. Bagnara; E. Guruceaga; O. Blanco; J. Celay; A. Martínez-Baztan; N. Casares; J.José Lasarte; T. MacCarthy; A. Melnick; J.Angel Martínez-Climent; S. Roa, Blood, 2019 05 30, 133, 22, p.2401-2412, (2019) PubMed

Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response., X. Agirre; C. Meydan; Y. Jiang; L. Garate; A.S. Doane; Z. Li; A. Verma; B. Paiva; J.I. Martín-Subero; O. Elemento; C.E. Mason; F. Prosper; A. Melnick, Nat Commun, 2019 02 18, 10, 1, p.821, (2019) PubMed

Emerging epigenetic-modulating therapies in lymphoma., D. Sermer; L. Pasqualucci; H.G. Wendel; A. Melnick; A. Younes, Nat Rev Clin Oncol, 2019 08, 16, 8, p.494-507, (2019) PubMed

BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection., B. Zhu; R. Zhang; C. Li; L. Jiang; M. Xiang; Z. Ye; H. Kita; A.M. Melnick; A.L. Dent; J. Sun, Proc Natl Acad Sci U S A, 2019 06 11, 116, 24, p.11888-11893, (2019) PubMed

Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition., D. Ennishi; K. Takata; W. Béguelin; G. Duns; A. Mottok; P. Farinha; A. Bashashati; S. Saberi; M. Boyle; B. Meissner; S. Ben-Neriah; B.W. Woolcock; A. Telenius; D. Lai; M. Teater; R. Kridel; K.J. Savage; L.H. Sehn; R.D. Morin; M.A. Marra; S.P. Shah; J.M. Connors; R.D. Gascoyne; D.W. Scott; A.M. Melnick; C. Steidl, Cancer Discov, 2019 04, 9, 4, p.546-563, (2019) PubMed

Role of chromosomal architecture in germinal center B cells and lymphomagenesis., M.A. Rivas; A.M. Melnick, Curr Opin Hematol, 2019 07, 26, 4, p.294-302, (2019) PubMed

2018

Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs., K.M. Noh; H. Wang; H.R. Kim; W. Wenderski; F. Fang; C.H. Li; S. Dewell; S.H. Hughes; A.M. Melnick; D.J. Patel; H. Li; D. Allis, Mol Cell, 2018 02 01, 69, 3, p.533, (2018) PubMed

How Biophysical Forces Regulate Human B Cell Lymphomas., F. Apoorva; A.M. Loiben; S.B. Shah; A. Purwada; L. Fontan; R. Goldstein; B.J. Kirby; A.M. Melnick; B.D. Cosgrove; A. Singh, Cell Rep, 2018 Apr 10, 23, 2, p.499-511, (2018) PubMed