Publications

2016

Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region., K.L. Bunting; D. Soong; R. Singh; Y. Jiang; W. Béguelin; D.W. Poloway; B.L. Swed; K. Hatzi; W. Reisacher; M. Teater; O. Elemento; A.M. Melnick, Immunity, 2016 09 20, 45, 3, p.497-512, (2016) PubMed

Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma., T. Dupont; S.Ning Yang; J. Patel; K. Hatzi; A. Malik; W. Tam; P. Martin; J. Leonard; A. Melnick; L. Cerchietti, Oncotarget, 2016 Jan 19, 7, 3, p.3520-32, (2016) PubMed

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis., W. Béguelin; M. Teater; M.D. Gearhart; M.Teresa Cal Fernández; R.L. Goldstein; M.G. Cardenas; K. Hatzi; M. Rosen; H. Shen; C.M. Corcoran; M.Y. Hamline; R.D. Gascoyne; R.L. Levine; O. Abdel-Wahab; J.D. Licht; R. Shaknovich; O. Elemento; V.J. Bardwell; A.M. Melnick, Cancer Cell, 2016 08 08, 30, 2, p.197-213, (2016) PubMed

A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations., D. Han; X. Lu; A.H. Shih; J. Nie; Q. You; M.Michelle Xu; A.M. Melnick; R.L. Levine; C. He, Mol Cell, 2016 08 18, 63, 4, p.711-719, (2016) PubMed

Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics., E.F. Robles; M. Mena-Varas; L. Barrio; S.V. Merino-Cortes; P. Balogh; M.Q. Du; T. Akasaka; A. Parker; S. Roa; C. Panizo; I. Martin-Guerrero; R. Siebert; V. Segura; X. Agirre; L. Macri-Pellizeri; B. Aldaz; A. Vilas-Zornoza; S. Zhang; S. Moody; M.Jose Calasanz; T. Tousseyn; C. Broccardo; P. Brousset; E. Campos-Sanchez; C. Cobaleda; I. Sanchez-Garcia; J.Luis Fernandez-Luna; R. Garcia-Muñoz; E. Pena; B. Bellosillo; A. Salar; M.Joao Baptista; J.Maria Hernandez-Rivas; M. Gonzalez; M.Jose Terol; J. Climent; A. Ferrandez; X. Sagaert; A.M. Melnick; F. Prosper; D.G. Oscier; Y.R. Carrasco; M.J.S. Dyer; J.A. Martinez-Climent, Nat Commun, 2016 06 14, 7, , p.11889, (2016) PubMed

The many layers of epigenetic dysfunction in B-cell lymphomas., Y. Jiang; P.M. Dominguez; A.M. Melnick, Curr Opin Hematol, 2016 07, 23, 4, p.377-84, (2016) PubMed

miR-181a negatively regulates NF-κB signaling and affects activated B-cell-like diffuse large B-cell lymphoma pathogenesis., G.A. Kozloski; X. Jiang; S. Bhatt; J. Ruiz; F. Vega; R. Shaknovich; A. Melnick; I.S. Lossos, Blood, 2016 06 09, 127, 23, p.2856-66, (2016) PubMed

Roles for small noncoding RNAs in silencing of retrotransposons in the mammalian brain., S. Nandi; D. Chandramohan; L. Fioriti; A.M. Melnick; J.M. Hébert; C.E. Mason; P. Rajasethupathy; E.R. Kandel, Proc Natl Acad Sci U S A, 2016 Nov 08, 113, 45, p.12697-12702, (2016) PubMed

SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents., W. Fiskus; V. Coothankandaswamy; J. Chen; H. Ma; K. Ha; D.T. Saenz; S.S. Krieger; C.P. Mill; B. Sun; P. Huang; J.S. Mumm; A.M. Melnick; K.N. Bhalla, Cancer Res, 2016 09 15, 76, 18, p.5467-78, (2016) PubMed

Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma., M.G. Cardenas; W. Yu; W. Béguelin; M.R. Teater; H. Geng; R.L. Goldstein; E. Oswald; K. Hatzi; S.N. Yang; J. Cohen; R. Shaknovich; K. Vanommeslaeghe; H. Cheng; D. Liang; H.Je Cho; J. Abbott; W. Tam; W. Du; J.P. Leonard; O. Elemento; L. Cerchietti; T. Cierpicki; F. Xue; A.D. MacKerell; A.M. Melnick, J Clin Invest, 2016 09 01, 126, 9, p.3351-62, (2016) PubMed