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Publications

2016

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling., O.A. Guryanova; K. Shank; B. Spitzer; L. Luciani; R.P. Koche; F.E. Garrett-Bakelman; C. Ganzel; B.H. Durham; A. Mohanty; G. Hoermann; S.A. Rivera; A.G. Chramiec; E. Pronier; L. Bastian; M.D. Keller; D. Tovbin; E. Loizou; A.R. Weinstein; A.Rodriguez Gonzalez; Y.K. Lieu; J.M. Rowe; F. Pastore; A.Sophia McKenney; A.V. Krivtsov; W.R. Sperr; J.R. Cross; C.E. Mason; M.S. Tallman; M.E. Arcila; O. Abdel-Wahab; S.A. Armstrong; S. Kubicek; P.B. Staber; M. Gönen; E.M. Paietta; A.M. Melnick; S.D. Nimer; S. Mukherjee; R.L. Levine, Nat Med, 2016 12, 22, 12, p.1488-1495, (2016) PubMed

Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region., K.L. Bunting; D. Soong; R. Singh; Y. Jiang; W. Béguelin; D.W. Poloway; B.L. Swed; K. Hatzi; W. Reisacher; M. Teater; O. Elemento; A.M. Melnick, Immunity, 2016 09 20, 45, 3, p.497-512, (2016) PubMed

Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas., J. Bayliss; P. Mukherjee; C. Lu; S.U. Jain; C. Chung; D. Martinez; B. Sabari; A.S. Margol; P. Panwalkar; A. Parolia; M. Pekmezci; R.C. McEachin; M. Cieslik; B. Tamrazi; B.A. Garcia; G. La Rocca; M. Santi; P.W. Lewis; C. Hawkins; A. Melnick; D. Allis; C.B. Thompson; A.M. Chinnaiyan; A.R. Judkins; S. Venneti, Sci Transl Med, 2016 11 23, 8, 366, p.366ra161, (2016) PubMed

Mutant IDH: a targetable driver of leukemic phenotypes linking metabolism, epigenetics and transcriptional regulation., F.E. Garrett-Bakelman; A.M. Melnick, Epigenomics, 2016 07, 8, 7, p.945-57, (2016) PubMed

Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status"., L.M. LaFave; W. Béguelin; R. Koche; M. Teater; B. Spitzer; A. Chramiec; E. Papalexi; M.D. Keller; T. Hricik; K. Konstantinoff; J.B. Micol; B. Durham; S.K. Knutson; J.E. Campbell; G. Blum; X. Shi; E.H. Doud; A.V. Krivtsov; Y.Rock Chung; I. Khodos; E. de Stanchina; O. Ouerfelli; P.S. Adusumilli; P.M. Thomas; N.L. Kelleher; M. Luo; H. Keilhack; O. Abdel-Wahab; A. Melnick; S.A. Armstrong; R.L. Levine, Nat Med, 2016 06 07, 22, 6, p.578-9, (2016) PubMed

DNMT3A Haploinsufficiency Transforms FLT3ITD Myeloproliferative Disease into a Rapid, Spontaneous, and Fully Penetrant Acute Myeloid Leukemia., S.E. Meyer; T. Qin; D.E. Muench; K. Masuda; M. Venkatasubramanian; E. Orr; L. Suarez; S.D. Gore; R. Delwel; E. Paietta; M.S. Tallman; H. Fernandez; A. Melnick; M.M. Le Beau; S. Kogan; N. Salomonis; M.E. Figueroa; L. Grimes, Cancer Discov, 2016 05, 6, 5, p.501-15, (2016) PubMed

Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas., B. Culjkovic-Kraljacic; T.M. Fernando; R. Marullo; N. Calvo-Vidal; A. Verma; S.N. Yang; F. Tabbò; M. Gaudiano; H. Zahreddine; R.L. Goldstein; J. Patel; T. Taldone; G. Chiosis; M. Ladetto; P. Ghione; R. Machiorlatti; O. Elemento; G. Inghirami; A. Melnick; K.L.B. Borden; L. Cerchietti, Blood, 2016 Feb 18, 127, 7, p.858-68, (2016) PubMed

SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents., W. Fiskus; V. Coothankandaswamy; J. Chen; H. Ma; K. Ha; D.T. Saenz; S.S. Krieger; C.P. Mill; B. Sun; P. Huang; J.S. Mumm; A.M. Melnick; K.N. Bhalla, Cancer Res, 2016 09 15, 76, 18, p.5467-78, (2016) PubMed

Roles for small noncoding RNAs in silencing of retrotransposons in the mammalian brain., S. Nandi; D. Chandramohan; L. Fioriti; A.M. Melnick; J.M. Hébert; C.E. Mason; P. Rajasethupathy; E.R. Kandel, Proc Natl Acad Sci U S A, 2016 Nov 08, 113, 45, p.12697-12702, (2016) PubMed

The epichaperome is an integrated chaperome network that facilitates tumour survival., A. Rodina; T. Wang; P. Yan; E.DaGama Gomes; M.P.S. Dunphy; N. Pillarsetty; J. Koren; J.F. Gerecitano; T. Taldone; H. Zong; E. Caldas-Lopes; M. Alpaugh; A. Corben; M. Riolo; B. Beattie; C. Pressl; R.I. Peter; C. Xu; R. Trondl; H.J. Patel; F. Shimizu; A. Bolaender; C. Yang; P. Panchal; M.F. Farooq; S. Kishinevsky; S. Modi; O. Lin; F. Chu; S. Patil; H. Erdjument-Bromage; P. Zanzonico; C. Hudis; L. Studer; G.J. Roboz; E. Cesarman; L. Cerchietti; R. Levine; A. Melnick; S.M. Larson; J.S. Lewis; M.L. Guzman; G. Chiosis, Nature, 2016 Oct 20, 538, 7625, p.397-401, (2016) PubMed