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Journal Article
Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity., De, Subhajyoti, Shaknovich Rita, Riester Markus, Elemento Olivier, Geng Huimin, Kormaksson Matthias, Jiang Yanwen, Woolcock Bruce, Johnson Nathalie, Polo Jose M., et al. , PLoS Genet, 2013, Volume 9, Issue 1, p.e1003137, (2013)
AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis., Teater, Matt, Dominguez Pilar M., Redmond David, Chen Zhengming, Ennishi Daisuke, Scott David W., Cimmino Luisa, Ghione Paola, Chaudhuri Jayanta, Gascoyne Randy D., et al. , Nat Commun, 2018 Jan 15, Volume 9, Issue 1, p.222, (2018)
BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells., Valls, Ester, Lobry Camille, Geng Huimin, Wang Ling, Cardenas Mariano, Rivas Martín, Cerchietti Leandro, Oh Philmo, Yang Shao Ning, Oswald Erin, et al. , Cancer Discov, 2017 May, Volume 7, Issue 5, p.506-521, (2017)
The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL., Ci, Weimin, Polo Jose M., Cerchietti Leandro, Shaknovich Rita, Wang Ling, Yang Shao Ning, Ye Kenny, Farinha Pedro, Horsman Douglas E., Gascoyne Randy D., et al. , Blood, 2009 May 28, Volume 113, Issue 22, p.5536-48, (2009)
Combinatorial targeting of nuclear export and translation of RNA inhibits aggressive B-cell lymphomas., Culjkovic-Kraljacic, Biljana, Fernando Tharu M., Marullo Rossella, Calvo-Vidal Nieves, Verma Akanksha, Yang ShaoNing, Tabbò Fabrizio, Gaudiano Marcello, Zahreddine Hiba, Goldstein Rebecca L., et al. , Blood, 2016 Feb 18, Volume 127, Issue 7, p.858-68, (2016)
CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas., Jiang, Yanwen, Ortega-Molina Ana, Geng Huimin, Ying Hsia-Yuan, Hatzi Katerina, Parsa Sara, McNally Dylan, Wang Ling, Doane Ashley S., Agirre Xabier, et al. , Cancer Discov, 2017 Jan, Volume 7, Issue 1, p.38-53, (2017)
Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas., Jiang, Yanwen, Redmond David, Nie Kui, Eng Ken W., Clozel Thomas, Martin Peter, Tan Leonard Hc, Melnick Ari M., Tam Wayne, and Elemento Olivier , Genome Biol, 2014 Aug 15, Volume 15, Issue 8, p.432, (2014)
DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID., Dominguez, Pilar M., Teater Matt, Chambwe Nyasha, Kormaksson Matthias, Redmond David, Ishii Jennifer, Vuong Bao, Chaudhuri Jayanta, Melnick Ari, Vasanthakumar Aparna, et al. , Cell Rep, 2015 Sep 29, Volume 12, Issue 12, p.2086-98, (2015)
DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma., Shaknovich, Rita, Geng Huimin, Johnson Nathalie A., Tsikitas Lucas, Cerchietti Leandro, Greally John M., Gascoyne Randy D., Elemento Olivier, and Melnick Ari , Blood, 2010 Nov 18, Volume 116, Issue 20, p.e81-9, (2010)
DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation., Shaknovich, Rita, Cerchietti Leandro, Tsikitas Lucas, Kormaksson Matthias, De Subhajyoti, Figueroa Maria E., Ballon Gianna, Yang Shao Ning, Weinhold Nils, Reimers Mark, et al. , Blood, 2011 Sep 29, Volume 118, Issue 13, p.3559-69, (2011)
Downregulation of FOXP1 is required during germinal center B-cell function., Sagardoy, Ainara, Martinez-Ferrandis Jose I., Roa Sergio, Bunting Karen L., Aznar María Angela, Elemento Olivier, Shaknovich Rita, Fontan Lorena, Fresquet Vicente, Perez-Roger Ignacio, et al. , Blood, 2013 May 23, Volume 121, Issue 21, p.4311-20, (2013)
Effective Combination Therapies for B-cell Lymphoma Predicted by a Virtual Disease Model., Du, Wei, Goldstein Rebecca, Jiang Yanwen, Aly Omar, Cerchietti Leandro, Melnick Ari, and Elemento Olivier , Cancer Res, 2017 Apr 15, Volume 77, Issue 8, p.1818-1830, (2017)
Epigenetic Identity in AML Depends on Disruption of Nonpromoter Regulatory Elements and Is Affected by Antagonistic Effects of Mutations in Epigenetic Modifiers., Glass, Jacob L., Hassane Duane, Wouters Bas J., Kunimoto Hiroyoshi, Avellino Roberto, Garrett-Bakelman Francine E., Guryanova Olga A., Bowman Robert, Redlich Shira, Intlekofer Andrew M., et al. , Cancer Discov, 2017 Aug, Volume 7, Issue 8, p.868-883, (2017)
Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression., Lin, Pei-Chun, Chiu Ya-Lin, Banerjee Samprit, Park Kyung, Mosquera Juan Miguel, Giannopoulou Eugenia, Alves Pedro, Tewari Ashutosh K., Gerstein Mark B., Beltran Himisha, et al. , Cancer Res, 2013 Feb 01, Volume 73, Issue 3, p.1232-44, (2013)
Epigenomic evolution in diffuse large B-cell lymphomas., Pan, Heng, Jiang Yanwen, Boi Michela, Tabbò Fabrizio, Redmond David, Nie Kui, Ladetto Marco, Chiappella Annalisa, Cerchietti Leandro, Shaknovich Rita, et al. , Nat Commun, 2015 Apr 20, Volume 6, p.6921, (2015)
EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis., Béguelin, Wendy, Teater Matt, Gearhart Micah D., Fernández María Teresa Cal, Goldstein Rebecca L., Cardenas Mariano G., Hatzi Katerina, Rosen Monica, Shen Hao, Corcoran Connie M., et al. , Cancer Cell, 2016 Aug 08, Volume 30, Issue 2, p.197-213, (2016)
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop., Béguelin, Wendy, Rivas Martín A., Fernández María T. Calvo, Teater Matt, Purwada Alberto, Redmond David, Shen Hao, Challman Matt F., Elemento Olivier, Singh Ankur, et al. , Nat Commun, 2017 Oct 12, Volume 8, Issue 1, p.877, (2017)
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation., Béguelin, Wendy, Popovic Relja, Teater Matt, Jiang Yanwen, Bunting Karen L., Rosen Monica, Shen Hao, Yang Shao Ning, Wang Ling, Ezponda Teresa, et al. , Cancer Cell, 2013 May 13, Volume 23, Issue 5, p.677-92, (2013)
EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis., Velichutina, Irina, Shaknovich Rita, Geng Huimin, Johnson Nathalie A., Gascoyne Randy D., Melnick Ari M., and Elemento Olivier , Blood, 2010 Dec 09, Volume 116, Issue 24, p.5247-55, (2010)
Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphoma., Jiang, Yanwen, T Soong David, Wang Ling, Melnick Ari M., and Elemento Olivier , PLoS One, 2012, Volume 7, Issue 7, p.e40332, (2012)
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture., Yusufova, Nevin, Kloetgen Andreas, Teater Matt, Osunsade Adewola, Camarillo Jeannie M., Chin Christopher R., Doane Ashley S., Venters Bryan J., Portillo-Ledesma Stephanie, Conway Joseph, et al. , Nature, 2021 Jan, Volume 589, Issue 7841, p.299-305, (2021)
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development., Ortega-Molina, Ana, Boss Isaac W., Canela Andres, Pan Heng, Jiang Yanwen, Zhao Chunying, Jiang Man, Hu Deqing, Agirre Xabier, Niesvizky Itamar, et al. , Nat Med, 2015 Oct, Volume 21, Issue 10, p.1199-208, (2015)
A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters., Hatzi, Katerina, Jiang Yanwen, Huang ChuanXin, Garrett-Bakelman Francine, Gearhart Micah D., Giannopoulou Eugenia G., Zumbo Paul, Kirouac Kevin, Bhaskara Srividya, Polo Jose M., et al. , Cell Rep, 2013 Aug 15, Volume 4, Issue 3, p.578-88, (2013)
Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia., Geng, Huimin, Brennan Sarah, Milne Thomas A., Chen Wei-Yi, Li Yushan, Hurtz Christian, Kweon Soo-Mi, Zickl Lynette, Shojaee Seyedmehdi, Neuberg Donna, et al. , Cancer Discov, 2012 Nov, Volume 2, Issue 11, p.1004-23, (2012)
Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response., Agirre, Xabier, Meydan Cem, Jiang Yanwen, Garate Leire, Doane Ashley S., Li Zhuoning, Verma Akanksha, Paiva Bruno, Martín-Subero José I., Elemento Olivier, et al. , Nat Commun, 2019 Feb 18, Volume 10, Issue 1, p.821, (2019)