Found 86 results
Filters: Author is Melnick, Ari M  [Clear All Filters]
2021
An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities., Flümann, Ruth, Rehkämper Tim, Nieper Pascal, Pfeiffer Pauline, Holzem Alessandra, Klein Sebastian, Bhatia Sanil, Kochanek Moritz, Kisis Ilmars, Pelzer Benedikt W., et al. , Blood Cancer Discov, 2021 01, Volume 2, Issue 1, p.70-91, (2021)
Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence., Duy, Cihangir, Li Meng, Teater Matt, Meydan Cem, Garrett-Bakelman Francine E., Lee Tak C., Chin Christopher R., Durmaz Ceyda, Kawabata Kimihito C., Dhimolea Eugen, et al. , Cancer Discov, 2021 06, Volume 11, Issue 6, p.1542-1561, (2021)
H1 histones control the epigenetic landscape by local chromatin compaction., Willcockson, Michael A., Healton Sean E., Weiss Cary N., Bartholdy Boris A., Botbol Yair, Mishra Laxmi N., Sidhwani Dhruv S., Wilson Tommy J., Pinto Hugo B., Maron Maxim I., et al. , Nature, 2021 01, Volume 589, Issue 7841, p.293-298, (2021)
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture., Yusufova, Nevin, Kloetgen Andreas, Teater Matt, Osunsade Adewola, Camarillo Jeannie M., Chin Christopher R., Doane Ashley S., Venters Bryan J., Portillo-Ledesma Stephanie, Conway Joseph, et al. , Nature, 2021 01, Volume 589, Issue 7841, p.299-305, (2021)
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation., Rivas, Martín A., Meydan Cem, Chin Christopher R., Challman Matt F., Kim Daleum, Bhinder Bhavneet, Kloetgen Andreas, Viny Aaron D., Teater Matt R., McNally Dylan R., et al. , Nat Immunol, 2021 02, Volume 22, Issue 2, p.240-253, (2021)
2020
Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers., Bezdan, Daniela, Grigorev Kirill, Meydan Cem, Vatter Fanny A. Pelissie, Cioffi Michele, Rao Varsha, MacKay Matthew, Nakahira Kiichi, Burnham Philip, Afshinnekoo Ebrahim, et al. , iScience, 2020 Dec 18, Volume 23, Issue 12, p.101844, (2020)
Clonal Hematopoiesis Before, During, and After Human Spaceflight., Mencia-Trinchant, Nuria, MacKay Matthew J., Chin Christopher, Afshinnekoo Ebrahim, Foox Jonathan, Meydan Cem, Butler Daniel, Mozsary Christopher, Vernice Nicholas A., Darby Charlotte, et al. , Cell Rep, 2020 12 08, Volume 33, Issue 10, p.108458, (2020)
The dangers of déjà vu: memory B cells as the cells of origin of ABC-DLBCLs., Venturutti, Leandro, and Melnick Ari M. , Blood, 2020 11 12, Volume 136, Issue 20, p.2263-2274, (2020)
Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response., Béguelin, Wendy, Teater Matt, Meydan Cem, Hoehn Kenneth B., Phillip Jude M., Soshnev Alexey A., Venturutti Leandro, Rivas Martín A., Calvo-Fernández María T., Gutierrez Johana, et al. , Cancer Cell, 2020 05 11, Volume 37, Issue 5, p.655-673.e11, (2020)
The oncogene BCL6 is up-regulated in glioblastoma in response to DNA damage, and drives survival after therapy., Fabre, Marie-Sophie, Stanton Nicole M., Slatter Tania L., Lee Samuel, Senanayake Dinindu, Gordon Rosemary M. A., M Castro Leticia, Rowe Matthew R., Taha Ahmad, Royds Janice A., et al. , PLoS One, 2020, Volume 15, Issue 4, p.e0231470, (2020)
Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma., Mondello, Patrizia, Tadros Saber, Teater Matt, Fontan Lorena, Chang Aaron Y., Jain Neeraj, Yang Haopeng, Singh Shailbala, Ying Hsia-Yuan, Chu Chi-Shuen, et al. , Cancer Discov, 2020 03, Volume 10, Issue 3, p.440-459, (2020)
Shotgun Transcriptome and Isothermal Profiling of SARS-CoV-2 Infection Reveals Unique Host Responses, Viral Diversification, and Drug Interactions., Butler, Daniel J., Mozsary Christopher, Meydan Cem, Danko David, Foox Jonathan, Rosiene Joel, Shaiber Alon, Afshinnekoo Ebrahim, MacKay Matthew, Sedlazeck Fritz J., et al. , bioRxiv, 2020 May 01, (2020)
Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML., Li, Sheng, Chen Xiaowen, Wang Jiahui, Meydan Cem, Glass Jacob L., Shih Alan H., Delwel Ruud, Levine Ross L., Mason Christopher E., and Melnick Ari M. , Cancer Discov, 2020 12, Volume 10, Issue 12, p.1934-1949, (2020)
Targeted detection and quantitation of histone modifications from 1,000 cells., Abshiru, Nebiyu A., Sikora Jacek W., Camarillo Jeannie M., Morris Juliette A., Compton Philip D., Lee Tak, Neelamraju Yaseswini, Haddox Samuel, Sheridan Caroline, Carroll Martin, et al. , PLoS One, 2020, Volume 15, Issue 10, p.e0240829, (2020)
TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate., Venturutti, Leandro, Teater Matt, Zhai Andrew, Chadburn Amy, Babiker Leena, Kim Daleum, Béguelin Wendy, Lee Tak C., Kim Youngjun, Chin Christopher R., et al. , Cell, 2020 07 23, Volume 182, Issue 2, p.297-316.e27, (2020)
The therapeutic landscape for cells engineered with chimeric antigen receptors., MacKay, Matthew, Afshinnekoo Ebrahim, Rub Jonathan, Hassan Ciaran, Khunte Mihir, Baskaran Nithyashri, Owens Bryan, Liu Lauren, Roboz Gail J., Guzman Monica L., et al. , Nat Biotechnol, 2020 02, Volume 38, Issue 2, p.233-244, (2020)
Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage., Chu, Chi-Shuen, Hellmuth Johannes C., Singh Rajat, Ying Hsia-Yuan, Skrabanek Lucy, Teater Matthew R., Doane Ashley S., Elemento Olivier, Melnick Ari M., and Roeder Robert G. , Mol Cell, 2020 12 03, Volume 80, Issue 5, p.845-861.e10, (2020)
2019
BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress., Fernando, Tharu M., Marullo Rossella, Gresely Benet Pera, Phillip Jude M., Yang Shao Ning, Lundell-Smith Geoffrey, Torregroza Ingrid, Ahn Haelee, Evans Todd, Gyorffy Balazs, et al. , Cancer Discov, 2019 05, Volume 9, Issue 5, p.662-679, (2019)
BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection., Zhu, Bibo, Zhang Ruixuan, Li Chaofan, Jiang Li, Xiang Min, Ye Zhenqing, Kita Hirohito, Melnick Ari M., Dent Alexander L., and Sun Jie , Proc Natl Acad Sci U S A, 2019 06 11, Volume 116, Issue 24, p.11888-11893, (2019)
Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL., Pastore, Alessandro, Gaiti Federico, Lu Sydney X., Brand Ryan M., Kulm Scott, Chaligne Ronan, Gu Hongcang, Huang Kevin Y., Stamenova Elena K., Béguelin Wendy, et al. , Nat Commun, 2019 04 23, Volume 10, Issue 1, p.1874, (2019)
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization., Gomes, Ana P., Ilter Didem, Low Vivien, Rosenzweig Adam, Shen Zih-Jie, Schild Tanya, Rivas Martín A., Er Ekrem E., McNally Dylan R., Mutvei Anders P., et al. , Cancer Cell, 2019 10 14, Volume 36, Issue 4, p.402-417.e13, (2019)
Ex vivo synthetic immune tissues with T cell signals for differentiating antigen-specific, high affinity germinal center B cells., Purwada, Alberto, Shah Shivem B., Béguelin Wendy, August Avery, Melnick Ari M., and Singh Ankur , Biomaterials, 2019 04, Volume 198, p.27-36, (2019)
An "EZ" Epigenetic Road to Leukemia Stem Cell Metabolic Reprogramming?, Li, Meng, and Melnick Ari M. , Cancer Discov, 2019 Sep, Volume 9, Issue 9, p.1158-1160, (2019)
Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis., Hatzi, Katerina, Geng Huimin, Doane Ashley S., Meydan Cem, LaRiviere Reed, Cardenas Mariano, Duy Cihangir, Shen Hao, Vidal Maria Nieves Cal, Baslan Timour, et al. , Nat Immunol, 2019 01, Volume 20, Issue 1, p.86-96, (2019)
The Impact of Heterogeneity on Single-Cell Sequencing., Goldman, Samantha L., MacKay Matthew, Afshinnekoo Ebrahim, Melnick Ari M., Wu Shuxiu, and Mason Christopher E. , Front Genet, 2019, Volume 10, p.8, (2019)