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Journal Article
An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities., Flümann, Ruth, Rehkämper Tim, Nieper Pascal, Pfeiffer Pauline, Holzem Alessandra, Klein Sebastian, Bhatia Sanil, Kochanek Moritz, Kisis Ilmars, Pelzer Benedikt W., et al. , Blood Cancer Discov, 2021 01, Volume 2, Issue 1, p.70-91, (2021)
BCL6 breaks occur at different AID sequence motifs in Ig-BCL6 and non-Ig-BCL6 rearrangements., Lu, Zhengfei, Tsai Albert G., Akasaka Takashi, Ohno Hitoshi, Jiang Yanwen, Melnick Ari M., Greisman Harvey A., and Lieber Michael R. , Blood, 2013 May 30, Volume 121, Issue 22, p.4551-4, (2013)
BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress., Fernando, Tharu M., Marullo Rossella, Gresely Benet Pera, Phillip Jude M., Yang Shao Ning, Lundell-Smith Geoffrey, Torregroza Ingrid, Ahn Haelee, Evans Todd, Gyorffy Balazs, et al. , Cancer Discov, 2019 05, Volume 9, Issue 5, p.662-679, (2019)
BCL6 is critical for the development of a diverse primary B cell repertoire., Duy, Cihangir, J Yu Jessica, Nahar Rahul, Swaminathan Srividya, Kweon Soo-Mi, Polo Jose M., Valls Ester, Klemm Lars, Shojaee Seyedmehdi, Cerchietti Leandro, et al. , J Exp Med, 2010 Jun 07, Volume 207, Issue 6, p.1209-21, (2010)
BCL6 modulates tissue neutrophil survival and exacerbates pulmonary inflammation following influenza virus infection., Zhu, Bibo, Zhang Ruixuan, Li Chaofan, Jiang Li, Xiang Min, Ye Zhenqing, Kita Hirohito, Melnick Ari M., Dent Alexander L., and Sun Jie , Proc Natl Acad Sci U S A, 2019 06 11, Volume 116, Issue 24, p.11888-11893, (2019)
BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia., Hurtz, Christian, Hatzi Katerina, Cerchietti Leandro, Braig Melanie, Park Eugene, Kim Yong-mi, Herzog Sebastian, Ramezani-Rad Parham, Jumaa Hassan, Müller Martin C., et al. , J Exp Med, 2011 Oct 24, Volume 208, Issue 11, p.2163-74, (2011)
The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis., Barish, Grant D., Yu Ruth T., Karunasiri Malith S., Becerra Diana, Kim Jason, Tseng Tiffany W., Tai Li-Jung, Leblanc Matthias, Diehl Cody, Cerchietti Leandro, et al. , Cell Metab, 2012 Apr 04, Volume 15, Issue 4, p.554-62, (2012)
CD99 is a therapeutic target on disease stem cells in myeloid malignancies., Chung, Stephen S., Eng William S., Hu Wenhuo, Khalaj Mona, Garrett-Bakelman Francine E., Tavakkoli Montreh, Levine Ross L., Carroll Martin, Klimek Virginia M., Melnick Ari M., et al. , Sci Transl Med, 2017 01 25, Volume 9, Issue 374, (2017)
Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers., Bezdan, Daniela, Grigorev Kirill, Meydan Cem, Vatter Fanny A. Pelissie, Cioffi Michele, Rao Varsha, MacKay Matthew, Nakahira Kiichi, Burnham Philip, Afshinnekoo Ebrahim, et al. , iScience, 2020 Dec 18, Volume 23, Issue 12, p.101844, (2020)
Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence., Duy, Cihangir, Li Meng, Teater Matt, Meydan Cem, Garrett-Bakelman Francine E., Lee Tak C., Chin Christopher R., Durmaz Ceyda, Kawabata Kimihito C., Dhimolea Eugen, et al. , Cancer Discov, 2021 06, Volume 11, Issue 6, p.1542-1561, (2021)
A clinical measure of DNA methylation predicts outcome in de novo acute myeloid leukemia., Luskin, Marlise R., Gimotty Phyllis A., Smith Catherine, Loren Alison W., Figueroa Maria E., Harrison Jenna, Sun Zhuoxin, Tallman Martin S., Paietta Elisabeth M., Litzow Mark R., et al. , JCI Insight, 2016 Jun 16, Volume 1, Issue 9, (2016)
Clonal Hematopoiesis Before, During, and After Human Spaceflight., Mencia-Trinchant, Nuria, MacKay Matthew J., Chin Christopher, Afshinnekoo Ebrahim, Foox Jonathan, Meydan Cem, Butler Daniel, Mozsary Christopher, Vernice Nicholas A., Darby Charlotte, et al. , Cell Rep, 2020 12 08, Volume 33, Issue 10, p.108458, (2020)
Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL., Pastore, Alessandro, Gaiti Federico, Lu Sydney X., Brand Ryan M., Kulm Scott, Chaligne Ronan, Gu Hongcang, Huang Kevin Y., Stamenova Elena K., Béguelin Wendy, et al. , Nat Commun, 2019 04 23, Volume 10, Issue 1, p.1874, (2019)
CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas., Jiang, Yanwen, Ortega-Molina Ana, Geng Huimin, Ying Hsia-Yuan, Hatzi Katerina, Parsa Sara, McNally Dylan, Wang Ling, Doane Ashley S., Agirre Xabier, et al. , Cancer Discov, 2017 01, Volume 7, Issue 1, p.38-53, (2017)
The dangers of déjà vu: memory B cells as the cells of origin of ABC-DLBCLs., Venturutti, Leandro, and Melnick Ari M. , Blood, 2020 11 12, Volume 136, Issue 20, p.2263-2274, (2020)
Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas., Jiang, Yanwen, Redmond David, Nie Kui, Eng Ken W., Clozel Thomas, Martin Peter, Tan Leonard Hc, Melnick Ari M., Tam Wayne, and Elemento Olivier , Genome Biol, 2014 Aug 15, Volume 15, Issue 8, p.432, (2014)
Derepression in the desert: the third workshop on clinical translation of epigenetics in cancer therapeutics., Zelent, Arthur, Petrie Kevin, Boix-Chornet Manuel, Melnick Ari M., Waxman Samuel, and Gore Steven D. , Cancer Res, 2008 Jul 01, Volume 68, Issue 13, p.4967-70, (2008)
Differentiation therapy for IDH1/2 mutant malignancies., Garrett-Bakelman, Francine E., and Melnick Ari M. , Cell Res, 2013 Aug, Volume 23, Issue 8, p.975-7, (2013)
Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia., Li, Sheng, Garrett-Bakelman Francine E., Chung Stephen S., Sanders Mathijs A., Hricik Todd, Rapaport Franck, Patel Jay, Dillon Richard, Vijay Priyanka, Brown Anna L., et al. , Nat Med, 2016 07, Volume 22, Issue 7, p.792-9, (2016)
DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling., Guryanova, Olga A., Shank Kaitlyn, Spitzer Barbara, Luciani Luisa, Koche Richard P., Garrett-Bakelman Francine E., Ganzel Chezi, Durham Benjamin H., Mohanty Abhinita, Hoermann Gregor, et al. , Nat Med, 2016 12, Volume 22, Issue 12, p.1488-1495, (2016)
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization., Gomes, Ana P., Ilter Didem, Low Vivien, Rosenzweig Adam, Shen Zih-Jie, Schild Tanya, Rivas Martín A., Er Ekrem E., McNally Dylan R., Mutvei Anders P., et al. , Cancer Cell, 2019 10 14, Volume 36, Issue 4, p.402-417.e13, (2019)
Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs., Noh, Kyung-Min, Wang Haibo, Kim Hyunjae R., Wenderski Wendy, Fang Fang, Li Charles H., Dewell Scott, Hughes Stephen H., Melnick Ari M., Patel Dinshaw J., et al. , Mol Cell, 2015 Jul 02, Volume 59, Issue 1, p.89-103, (2015)
Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs., Noh, Kyung-Min, Wang Haibo, Kim Hyunjae R., Wenderski Wendy, Fang Fang, Li Charles H., Dewell Scott, Hughes Stephen H., Melnick Ari M., Patel Dinshaw J., et al. , Mol Cell, 2018 02 01, Volume 69, Issue 3, p.533, (2018)
Enhanced reduced representation bisulfite sequencing for assessment of DNA methylation at base pair resolution., Garrett-Bakelman, Francine E., Sheridan Caroline K., Kacmarczyk Thadeous J., Ishii Jennifer, Betel Doron, Alonso Alicia, Mason Christopher E., Figueroa Maria E., and Melnick Ari M. , J Vis Exp, 2015 Feb 24, Issue 96, p.e52246, (2015)
Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression., Lin, Pei-Chun, Chiu Ya-Lin, Banerjee Samprit, Park Kyung, Mosquera Juan Miguel, Giannopoulou Eugenia, Alves Pedro, Tewari Ashutosh K., Gerstein Mark B., Beltran Himisha, et al. , Cancer Res, 2013 Feb 01, Volume 73, Issue 3, p.1232-44, (2013)