The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.
Ci, Weimin, Polo Jose M., Cerchietti Leandro, Shaknovich Rita, Wang Ling, Yang Shao Ning, Ye Kenny, Farinha Pedro, Horsman Douglas E., Gascoyne Randy D., et al.
, Blood, 2009 May 28, Volume 113, Issue 22, p.5536-48, (2009)
BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells.
Ranuncolo, Stella M., Polo Jose M., and Melnick Ari
, Blood Cells Mol Dis, 2008 Jul-Aug, Volume 41, Issue 1, p.95-9, (2008)
BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms.
Parekh, Samir, Polo Jose M., Shaknovich Rita, Juszczynski Przemyslaw, Lev Paola, Ranuncolo Stella M., Yin Yingnan, Klein Ulf, Cattoretti Giorgio, Favera Riccardo Dalla, et al.
, Blood, 2007 Sep 15, Volume 110, Issue 6, p.2067-74, (2007)
BCL6 is critical for the development of a diverse primary B cell repertoire.
Duy, Cihangir, J Yu Jessica, Nahar Rahul, Swaminathan Srividya, Kweon Soo-Mi, Polo Jose M., Valls Ester, Klemm Lars, Shojaee Seyedmehdi, Cerchietti Leandro, et al.
, J Exp Med, 2010 Jun 07, Volume 207, Issue 6, p.1209-21, (2010)
B-cell lymphoma 6 and the molecular pathogenesis of diffuse large B-cell lymphoma.
Ci, Weimin, Polo Jose M., and Melnick Ari
, Curr Opin Hematol, 2008 Jul, Volume 15, Issue 4, p.381-90, (2008)