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Journal Article
Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis., Alvarez, Hector, Opalinska Joanna, Zhou Li, Sohal Davendra, Fazzari Melissa J., Yu Yiting, Montagna Christina, Montgomery Elizabeth A., Canto Marcia, Dunbar Kerry B., et al. , PLoS Genet, 2011 Mar, Volume 7, Issue 3, p.e1001356, (2011)
Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers., Agirre, Xabier, Castellano Giancarlo, Pascual Marien, Heath Simon, Kulis Marta, Segura Victor, Bergmann Anke, Esteve Anna, Merkel Angelika, Raineri Emanuele, et al. , Genome Res, 2015 Apr, Volume 25, Issue 4, p.478-87, (2015)
Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage., Chu, Chi-Shuen, Hellmuth Johannes C., Singh Rajat, Ying Hsia-Yuan, Skrabanek Lucy, Teater Matthew R., Doane Ashley S., Elemento Olivier, Melnick Ari M., and Roeder Robert G. , Mol Cell, 2020 Dec 03, Volume 80, Issue 5, p.845-861.e10, (2020)
Transcriptome sequencing reveals thousands of novel long non-coding RNAs in B cell lymphoma., Verma, Akanksha, Jiang Yanwen, Du Wei, Fairchild Lauren, Melnick Ari, and Elemento Olivier , Genome Med, 2015 Nov 01, Volume 7, p.110, (2015)
Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas., Polo, Jose M., Juszczynski Przemyslaw, Monti Stefano, Cerchietti Leandro, Ye Kenny, Greally John M., Shipp Margaret, and Melnick Ari , Proc Natl Acad Sci U S A, 2007 Feb 27, Volume 104, Issue 9, p.3207-12, (2007)
Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies., Nayar, Utthara, Lu Pin, Goldstein Rebecca L., Vider Jelena, Ballon Gianna, Rodina Anna, Taldone Tony, Erdjument-Bromage Hediye, Chomet Max, Blasberg Ronald, et al. , Blood, 2013 Oct 17, Volume 122, Issue 16, p.2837-47, (2013)
SYK inhibition and response prediction in diffuse large B-cell lymphoma., Cheng, Shuhua, Coffey Greg, X Zhang Hannah, Shaknovich Rita, Song Zibo, Lu Pin, Pandey Anjali, Melnick Ari M., Sinha Uma, and Y Wang Lynn , Blood, 2011 Dec 08, Volume 118, Issue 24, p.6342-52, (2011)
A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis., Sun, Xiao-Jian, Wang Zhanxin, Wang Lan, Jiang Yanwen, Kost Nils, T Soong David, Chen Wei-Yi, Tang Zhanyun, Nakadai Tomoyoshi, Elemento Olivier, et al. , Nature, 2013 Aug 01, Volume 500, Issue 7460, p.93-7, (2013)
Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth., Fontan, Lorena, Qiao Qi, Hatcher John M., Casalena Gabriella, Us Ilkay, Teater Matt, Durant Matt, Du Guangyan, Xia Min, Bilchuk Natalia, et al. , J Clin Invest, 2018 Oct 01, Volume 128, Issue 10, p.4397-4412, (2018)
SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents., Fiskus, Warren, Coothankandaswamy Veena, Chen Jianguang, Ma Hongwei, Ha Kyungsoo, Saenz Dyana T., Krieger Stephanie S., Mill Christopher P., Sun Baohua, Huang Peng, et al. , Cancer Res, 2016 09 15, Volume 76, Issue 18, p.5467-78, (2016)
Sequential transcription factor targeting for diffuse large B-cell lymphomas., Cerchietti, Leandro C., Polo Jose M., Da Silva Gustavo F., Farinha Pedro, Shaknovich Rita, Gascoyne Randy D., Dowdy Steven F., and Melnick Ari , Cancer Res, 2008 May 01, Volume 68, Issue 9, p.3361-9, (2008)
Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma., Mondello, Patrizia, Tadros Saber, Teater Matt, Fontan Lorena, Chang Aaron Y., Jain Neeraj, Yang Haopeng, Singh Shailbala, Ying Hsia-Yuan, Chu Chi-Shuen, et al. , Cancer Discov, 2020 Mar, Volume 10, Issue 3, p.440-459, (2020)
SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells., Hammerich-Hille, Stephanie, Kaipparettu Benny A., Tsimelzon Anna, Creighton Chad J., Jiang Shiming, Polo Jose M., Melnick Ari, Meyer Rene, and Oesterreich Steffi , J Biol Chem, 2010 Feb 05, Volume 285, Issue 6, p.3608-3616, (2010)
RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction., Wilkinson, Adam C., Ballabio Erica, Geng Huimin, North Phillip, Tapia Marta, Kerry Jon, Biswas Debabrata, Roeder Robert G., C Allis David, Melnick Ari, et al. , Cell Rep, 2013 Jan 31, Volume 3, Issue 1, p.116-27, (2013)
Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma., Cardenas, Mariano G., Yu Wenbo, Béguelin Wendy, Teater Matthew R., Geng Huimin, Goldstein Rebecca L., Oswald Erin, Hatzi Katerina, Yang Shao-Ning, Cohen Joanna, et al. , J Clin Invest, 2016 09 01, Volume 126, Issue 9, p.3351-62, (2016)
PTEN opposes negative selection and enables oncogenic transformation of pre-B cells., Shojaee, Seyedmehdi, Chan Lai N., Buchner Maike, Cazzaniga Valeria, Cosgun Kadriye Nehir, Geng Huimin, Qiu Yi Hua, von Minden Marcus Dühren, Ernst Thomas, Hochhaus Andreas, et al. , Nat Med, 2016 Apr, Volume 22, Issue 4, p.379-87, (2016)
Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting., Schafer, Eric, Irizarry Rafael, Negi Sandeep, McIntyre Emily, Small Donald, Figueroa Maria E., Melnick Ari, and Brown Patrick , Blood, 2010 Jun 10, Volume 115, Issue 23, p.4798-809, (2010)
PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival., Lu, Xiaoqing, Fernando Tharu M., Lossos Chen, Yusufova Nevin, Liu Fan, Fontan Lorena, Durant Matthew, Geng Huimin, Melnick Jacob, Luo Yuan, et al. , Blood, 2018 Nov 08, Volume 132, Issue 19, p.2026-2039, (2018)
PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex., Vu, Ly P., Perna Fabiana, Wang Lan, Voza Francesca, Figueroa Maria E., Tempst Paul, Erdjument-Bromage Hediye, Gao Rui, Chen Sisi, Paietta Elisabeth, et al. , Cell Rep, 2013 Dec 26, Volume 5, Issue 6, p.1625-38, (2013)
Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma., Goldstein, Rebecca L., Yang Shao Ning, Taldone Tony, Chang Betty, Gerecitano John, Elenitoba-Johnson Kojo, Shaknovich Rita, Tam Wayne, Leonard John P., Chiosis Gabriela, et al. , J Clin Invest, 2015 Nov 03, Volume 125, Issue 12, p.4559-71, (2015)
A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo., Cerchietti, Leandro C., Yang Shao Ning, Shaknovich Rita, Hatzi Katerina, Polo Jose M., Chadburn Amy, Dowdy Steven F., and Melnick Ari , Blood, 2009 Apr 09, Volume 113, Issue 15, p.3397-405, (2009)
ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia., Maes, Tamara, Mascaró Cristina, Tirapu Iñigo, Estiarte Angels, Ciceri Filippo, Lunardi Serena, Guibourt Nathalie, Perdones Alvaro, Lufino Michele M. P., Somervaille Tim C. P., et al. , Cancer Cell, 2018 Mar 12, Volume 33, Issue 3, p.495-511.e12, (2018)
The oncogene BCL6 is up-regulated in glioblastoma in response to DNA damage, and drives survival after therapy., Fabre, Marie-Sophie, Stanton Nicole M., Slatter Tania L., Lee Samuel, Senanayake Dinindu, Gordon Rosemary M. A., M Castro Leticia, Rowe Matthew R., Taha Ahmad, Royds Janice A., et al. , PLoS One, 2020, Volume 15, Issue 4, p.e0231470, (2020)
Notch activation inhibits AML growth and survival: a potential therapeutic approach., Kannan, Sankaranarayanan, Sutphin Robert M., Hall Mandy G., Golfman Leonard S., Fang Wendy, Nolo Riitta M., Akers Lauren J., Hammitt Richard A., McMurray John S., Kornblau Steven M., et al. , J Exp Med, 2013 Feb 11, Volume 210, Issue 2, p.321-37, (2013)
Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program., Park, Sun-Mi, Gönen Mithat, Vu Ly, Minuesa Gerard, Tivnan Patrick, Barlowe Trevor S., Taggart James, Lu Yuheng, Deering Raquel P., Hacohen Nir, et al. , J Clin Invest, 2015 Mar 02, Volume 125, Issue 3, p.1286-98, (2015)