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Found 18 results
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Gene Silencing
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2021
H1 histones control the epigenetic landscape by local chromatin compaction.
,
Willcockson, Michael A.
,
Healton Sean E.
,
Weiss Cary N.
,
Bartholdy Boris A.
,
Botbol Yair
,
Mishra Laxmi N.
,
Sidhwani Dhruv S.
,
Wilson Tommy J.
,
Pinto Hugo B.
,
Maron Maxim I.
, et al.
, Nature, 2021 Jan, Volume 589, Issue 7841, p.293-298, (2021)
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.
,
Yusufova, Nevin
,
Kloetgen Andreas
,
Teater Matt
,
Osunsade Adewola
,
Camarillo Jeannie M.
,
Chin Christopher R.
,
Doane Ashley S.
,
Venters Bryan J.
,
Portillo-Ledesma Stephanie
,
Conway Joseph
, et al.
, Nature, 2021 Jan, Volume 589, Issue 7841, p.299-305, (2021)
2019
Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL.
,
Pastore, Alessandro
,
Gaiti Federico
,
Lu Sydney X.
,
Brand Ryan M.
,
Kulm Scott
,
Chaligne Ronan
,
Gu Hongcang
,
Huang Kevin Y.
,
Stamenova Elena K.
,
Béguelin Wendy
, et al.
, Nat Commun, 2019 Apr 23, Volume 10, Issue 1, p.1874, (2019)
2017
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.
,
Béguelin, Wendy
,
Rivas Martín A.
,
Fernández María T. Calvo
,
Teater Matt
,
Purwada Alberto
,
Redmond David
,
Shen Hao
,
Challman Matt F.
,
Elemento Olivier
,
Singh Ankur
, et al.
, Nat Commun, 2017 Oct 12, Volume 8, Issue 1, p.877, (2017)
Genetic and epigenetic inactivation of controls mTORC1 and response to EZH2 inhibition in follicular lymphoma.
,
Oricchio, Elisa
,
Katanayeva Natalya
,
Donaldson Maria Christine
,
Sungalee Stephanie
,
Pasion Joyce P.
,
Béguelin Wendy
,
Battistello Elena
,
Sanghvi Viraj R.
,
Jiang Man
,
Jiang Yanwen
, et al.
, Sci Transl Med, 2017 Jun 28, Volume 9, Issue 396, (2017)
is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells.
,
Kunimoto, Hiroyoshi
,
McKenney Anna Sophia
,
Meydan Cem
,
Shank Kaitlyn
,
Nazir Abbas
,
Rapaport Franck
,
Durham Benjamin
,
Garrett-Bakelman Francine E.
,
Pronier Elodie
,
Shih Alan H.
, et al.
, Blood, 2017 Mar 30, Volume 129, Issue 13, p.1779-1790, (2017)
2016
The many layers of epigenetic dysfunction in B-cell lymphomas.
,
Jiang, Yanwen
,
Dominguez Pilar M.
, and
Melnick Ari M.
, Curr Opin Hematol, 2016 Jul, Volume 23, Issue 4, p.377-84, (2016)
2015
Mutational cooperativity linked to combinatorial epigenetic gain of function in acute myeloid leukemia.
,
Shih, Alan H.
,
Jiang Yanwen
,
Meydan Cem
,
Shank Kaitlyn
,
Pandey Suveg
,
Barreyro Laura
,
Antony-Debre Ileana
,
Viale Agnes
,
Socci Nicholas
,
Sun Yongming
, et al.
, Cancer Cell, 2015 Apr 13, Volume 27, Issue 4, p.502-15, (2015)
2013
Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity.
,
De, Subhajyoti
,
Shaknovich Rita
,
Riester Markus
,
Elemento Olivier
,
Geng Huimin
,
Kormaksson Matthias
,
Jiang Yanwen
,
Woolcock Bruce
,
Johnson Nathalie
,
Polo Jose M.
, et al.
, PLoS Genet, 2013, Volume 9, Issue 1, p.e1003137, (2013)
2012
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.
,
Abdel-Wahab, Omar
,
Adli Mazhar
,
LaFave Lindsay M.
,
Gao Jie
,
Hricik Todd
,
Shih Alan H.
,
Pandey Suveg
,
Patel Jay P.
,
Chung Young Rock
,
Koche Richard
, et al.
, Cancer Cell, 2012 Aug 14, Volume 22, Issue 2, p.180-93, (2012)
2011
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.
,
Moran-Crusio, Kelly
,
Reavie Linsey
,
Shih Alan
,
Abdel-Wahab Omar
,
Ndiaye-Lobry Delphine
,
Lobry Camille
,
Figueroa Maria E.
,
Vasanthakumar Aparna
,
Patel Jay
,
Zhao Xinyang
, et al.
, Cancer Cell, 2011 Jul 12, Volume 20, Issue 1, p.11-24, (2011)
2010
EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis.
,
Velichutina, Irina
,
Shaknovich Rita
,
Geng Huimin
,
Johnson Nathalie A.
,
Gascoyne Randy D.
,
Melnick Ari M.
, and
Elemento Olivier
, Blood, 2010 Dec 09, Volume 116, Issue 24, p.5247-55, (2010)
Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting.
,
Schafer, Eric
,
Irizarry Rafael
,
Negi Sandeep
,
McIntyre Emily
,
Small Donald
,
Figueroa Maria E.
,
Melnick Ari
, and
Brown Patrick
, Blood, 2010 Jun 10, Volume 115, Issue 23, p.4798-809, (2010)
2009
Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features.
,
Figueroa, Maria E.
,
Wouters Bas J.
,
Skrabanek Lucy
,
Glass Jacob
,
Li Yushan
,
Erpelinck-Verschueren Claudia A. J.
,
Langerak Anton W.
,
Löwenberg Bob
,
Fazzari Melissa
,
Greally John M.
, et al.
, Blood, 2009 Mar 19, Volume 113, Issue 12, p.2795-804, (2009)
2008
Kaiso contributes to DNA methylation-dependent silencing of tumor suppressor genes in colon cancer cell lines.
,
Lopes, Eloisi C.
,
Valls Ester
,
Figueroa Maria E.
,
Mazur Alexander
,
Meng Fan-Guo
,
Chiosis Gabriela
,
Laird Peter W.
,
Schreiber-Agus Nicole
,
Greally John M.
,
Prokhortchouk Egor
, et al.
, Cancer Res, 2008 Sep 15, Volume 68, Issue 18, p.7258-63, (2008)
2007
Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR.
,
Ranuncolo, Stella Maris
,
Polo Jose M.
,
Dierov Jamil
,
Singer Michael
,
Kuo Tracy
,
Greally John
,
Green Roland
,
Carroll Martin
, and
Melnick Ari
, Nat Immunol, 2007 Jul, Volume 8, Issue 7, p.705-14, (2007)
2005
The theoretical basis of transcriptional therapy of cancer: can it be put into practice?
,
Melnick, Ari M.
,
Adelson Kerin
, and
Licht Jonathan D.
, J Clin Oncol, 2005 Jun 10, Volume 23, Issue 17, p.3957-70, (2005)
2004
The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT.
,
Takahashi, Shinichiro
,
McConnell Melanie J.
,
Harigae Hideo
,
Kaku Mitsuo
,
Sasaki Takeshi
,
Melnick Ari M.
, and
Licht Jonathan D.
, Blood, 2004 Jun 15, Volume 103, Issue 12, p.4650-8, (2004)