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Found 27 results
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Proto-Oncogene Proteins
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A
Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain.
,
K Ahmad, Farid
,
Melnick Ari
,
Lax Stuart
,
Bouchard Denis
,
Liu Jun
,
Kiang Chih-Li
,
Mayer Sebastian
,
Takahashi Shinichiro
,
Licht Jonathan D.
, and
Prive Gilbert G.
, Mol Cell, 2003 Dec, Volume 12, Issue 6, p.1551-64, (2003)
B
EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.
,
Béguelin, Wendy
,
Teater Matt
,
Gearhart Micah D.
,
Fernández María Teresa Cal
,
Goldstein Rebecca L.
,
Cardenas Mariano G.
,
Hatzi Katerina
,
Rosen Monica
,
Shen Hao
,
Corcoran Connie M.
, et al.
, Cancer Cell, 2016 Aug 08, Volume 30, Issue 2, p.197-213, (2016)
Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis.
,
Busque, Lambert
,
Patel Jay P.
,
Figueroa Maria E.
,
Vasanthakumar Aparna
,
Provost Sylvie
,
Hamilou Zineb
,
Mollica Luigina
,
Li Juan
,
Viale Agnes
,
Heguy Adriana
, et al.
, Nat Genet, 2012 Nov, Volume 44, Issue 11, p.1179-81, (2012)
C
A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo.
,
Cerchietti, Leandro C.
,
Ghetu Alexandru F.
,
Zhu Xiao
,
Da Silva Gustavo F.
,
Zhong Shijun
,
Matthews Marilyn
,
Bunting Karen L.
,
Polo Jose M.
,
Farès Christophe
,
Arrowsmith Cheryl H.
, et al.
, Cancer Cell, 2010 Apr 13, Volume 17, Issue 4, p.400-11, (2010)
ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein.
,
Chevallier, Nathalie
,
Corcoran Connie M.
,
Lennon Christine
,
Hyjek Elizabeth
,
Chadburn Amy
,
Bardwell Vivian J.
,
Licht Jonathan D.
, and
Melnick Ari
, Blood, 2004 Feb 15, Volume 103, Issue 4, p.1454-63, (2004)
Identification of LMO2 transcriptome and interactome in diffuse large B-cell lymphoma.
,
Cubedo, Elena
,
Gentles Andrew J.
,
Huang ChuanXin
,
Natkunam Yasodha
,
Bhatt Shruti
,
Lu Xiaoqing
,
Jiang Xiaoyu
,
Romero-Camarero Isabel
,
Freud Aharon
,
Zhao Shuchun
, et al.
, Blood, 2012 Jun 07, Volume 119, Issue 23, p.5478-91, (2012)
D
TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.
,
Dominguez, Pilar M.
,
Ghamlouch Hussein
,
Rosikiewicz Wojciech
,
Kumar Parveen
,
Béguelin Wendy
,
Fontan Lorena
,
Rivas Martín A.
,
Pawlikowska Patrycja
,
Armand Marine
,
Mouly Enguerran
, et al.
, Cancer Discov, 2018 Dec, Volume 8, Issue 12, p.1632-1653, (2018)
Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma.
,
Dupont, Thibault
,
Yang Shao Ning
,
Patel Jayeshkumar
,
Hatzi Katerina
,
Malik Alka
,
Tam Wayne
,
Martin Peter
,
Leonard John
,
Melnick Ari
, and
Cerchietti Leandro
, Oncotarget, 2016 Jan 19, Volume 7, Issue 3, p.3520-32, (2016)
Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML.
,
Duy, Cihangir
,
Teater Matt
,
Garrett-Bakelman Francine E.
,
Lee Tak C.
,
Meydan Cem
,
Glass Jacob L.
,
Li Meng
,
Hellmuth Johannes C.
,
Mohammad Helai P.
,
Smitheman Kimberly N.
, et al.
, Cancer Discov, 2019 Jul, Volume 9, Issue 7, p.872-889, (2019)
F
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
,
Figueroa, Maria E.
,
Abdel-Wahab Omar
,
Lu Chao
,
Ward Patrick S.
,
Patel Jay
,
Shih Alan
,
Li Yushan
,
Bhagwat Neha
,
Vasanthakumar Aparna
,
Fernandez Hugo F.
, et al.
, Cancer Cell, 2010 Dec 14, Volume 18, Issue 6, p.553-67, (2010)
G
Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia.
,
Geng, Huimin
,
Hurtz Christian
,
Lenz Kyle B.
,
Chen Zhengshan
,
Baumjohann Dirk
,
Thompson Sarah
,
Goloviznina Natalya A.
,
Chen Wei-Yi
,
Huan Jianya
,
LaTocha Dorian
, et al.
, Cancer Cell, 2015 Mar 09, Volume 27, Issue 3, p.409-25, (2015)
Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer.
,
Ghetu, Alexandru F.
,
Corcoran Connie M.
,
Cerchietti Leandro
,
Bardwell Vivian J.
,
Melnick Ari
, and
Prive Gilbert G.
, Mol Cell, 2008 Feb 15, Volume 29, Issue 3, p.384-91, (2008)
H
A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.
,
Han, Dali
,
Lu Xingyu
,
Shih Alan H.
,
Nie Ji
,
You Qiancheng
,
Xu Meng Michelle
,
Melnick Ari M.
,
Levine Ross L.
, and
He Chuan
, Mol Cell, 2016 Aug 18, Volume 63, Issue 4, p.711-719, (2016)
J
The many layers of epigenetic dysfunction in B-cell lymphomas.
,
Jiang, Yanwen
,
Dominguez Pilar M.
, and
Melnick Ari M.
, Curr Opin Hematol, 2016 Jul, Volume 23, Issue 4, p.377-84, (2016)
K
Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity.
,
Kunimoto, Hiroyoshi
,
Meydan Cem
,
Nazir Abbas
,
Whitfield Justin
,
Shank Kaitlyn
,
Rapaport Franck
,
Maher Rebecca
,
Pronier Elodie
,
Meyer Sara C.
,
Garrett-Bakelman Francine E.
, et al.
, Cancer Cell, 2018 Jan 08, Volume 33, Issue 1, p.44-59.e8, (2018)
is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells.
,
Kunimoto, Hiroyoshi
,
McKenney Anna Sophia
,
Meydan Cem
,
Shank Kaitlyn
,
Nazir Abbas
,
Rapaport Franck
,
Durham Benjamin
,
Garrett-Bakelman Francine E.
,
Pronier Elodie
,
Shih Alan H.
, et al.
, Blood, 2017 Mar 30, Volume 129, Issue 13, p.1779-1790, (2017)
M
AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein.
,
Melnick, A
,
Carlile G W.
,
McConnell M J.
,
Polinger A
,
Hiebert S W.
, and
Licht J D.
, Blood, 2000 Dec 01, Volume 96, Issue 12, p.3939-47, (2000)
Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.
,
Melnick, Ari
,
Carlile Graeme
,
K Ahmad Farid
,
Kiang Chih-Li
,
Corcoran Connie
,
Bardwell Vivian
,
Prive Gilbert G.
, and
Licht Jonathan D.
, Mol Cell Biol, 2002 Mar, Volume 22, Issue 6, p.1804-18, (2002)
The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein.
,
Melnick, A M.
,
Westendorf J J.
,
Polinger A
,
Carlile G W.
,
Arai S
,
Ball H J.
,
Lutterbach B
,
Hiebert S W.
, and
Licht J D.
, Mol Cell Biol, 2000 Mar, Volume 20, Issue 6, p.2075-86, (2000)
CtBP is an essential corepressor for BCL6 autoregulation.
,
Mendez, Lourdes M.
,
Polo Jose M.
,
J Yu Jessica
,
Krupski Melissa
,
B Ding Belinda
,
Melnick Ari
, and
B Ye Hilda
, Mol Cell Biol, 2008 Apr, Volume 28, Issue 7, p.2175-86, (2008)
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.
,
Moran-Crusio, Kelly
,
Reavie Linsey
,
Shih Alan
,
Abdel-Wahab Omar
,
Ndiaye-Lobry Delphine
,
Lobry Camille
,
Figueroa Maria E.
,
Vasanthakumar Aparna
,
Patel Jay
,
Zhao Xinyang
, et al.
, Cancer Cell, 2011 Jul 12, Volume 20, Issue 1, p.11-24, (2011)
N
Methylome profiling reveals distinct alterations in phenotypic and mutational subgroups of myeloproliferative neoplasms.
,
Nischal, Sangeeta
,
Bhattacharyya Sanchari
,
Christopeit Maximilian
,
Yu Yiting
,
Zhou Li
,
Bhagat Tushar D.
,
Sohal Davendra
,
Will Britta
,
Mo Yongkai
,
Suzuki Masako
, et al.
, Cancer Res, 2013 Feb 01, Volume 73, Issue 3, p.1076-85, (2013)
P
Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.
,
Polo, Jose M.
,
Dell'Oso Tania
,
Ranuncolo Stella Maris
,
Cerchietti Leandro
,
Beck David
,
Da Silva Gustavo F.
,
Prive Gilbert G.
,
Licht Jonathan D.
, and
Melnick Ari
, Nat Med, 2004 Dec, Volume 10, Issue 12, p.1329-35, (2004)
R
DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.
,
Rampal, Raajit
,
Alkalin Altuna
,
Madzo Jozef
,
Vasanthakumar Aparna
,
Pronier Elodie
,
Patel Jay
,
Li Yushan
,
Ahn Jihae
,
Abdel-Wahab Omar
,
Shih Alan
, et al.
, Cell Rep, 2014 Dec 11, Volume 9, Issue 5, p.1841-1855, (2014)
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
,
Rivas, Martín A.
,
Meydan Cem
,
Chin Christopher R.
,
Challman Matt F.
,
Kim Daleum
,
Bhinder Bhavneet
,
Kloetgen Andreas
,
Viny Aaron D.
,
Teater Matt R.
,
McNally Dylan R.
, et al.
, Nat Immunol, 2021 Feb, Volume 22, Issue 2, p.240-253, (2021)
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