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2020
Clonal Hematopoiesis Before, During, and After Human Spaceflight., Mencia-Trinchant, Nuria, MacKay Matthew J., Chin Christopher, Afshinnekoo Ebrahim, Foox Jonathan, Meydan Cem, Butler Daniel, Mozsary Christopher, Vernice Nicholas A., Darby Charlotte, et al. , Cell Rep, 2020 Dec 08, Volume 33, Issue 10, p.108458, (2020)
The dangers of déjà vu: memory B cells as the cells of origin of ABC-DLBCLs., Venturutti, Leandro, and Melnick Ari M. , Blood, 2020 Nov 12, Volume 136, Issue 20, p.2263-2274, (2020)
Epigenetic Mechanisms in Leukemias and Lymphomas., Duy, Cihangir, Béguelin Wendy, and Melnick Ari , Cold Spring Harb Perspect Med, 2020 Dec 01, Volume 10, Issue 12, (2020)
Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response., Béguelin, Wendy, Teater Matt, Meydan Cem, Hoehn Kenneth B., Phillip Jude M., Soshnev Alexey A., Venturutti Leandro, Rivas Martín A., Calvo-Fernández María T., Gutierrez Johana, et al. , Cancer Cell, 2020 May 11, Volume 37, Issue 5, p.655-673.e11, (2020)
The oncogene BCL6 is up-regulated in glioblastoma in response to DNA damage, and drives survival after therapy., Fabre, Marie-Sophie, Stanton Nicole M., Slatter Tania L., Lee Samuel, Senanayake Dinindu, Gordon Rosemary M. A., M Castro Leticia, Rowe Matthew R., Taha Ahmad, Royds Janice A., et al. , PLoS One, 2020, Volume 15, Issue 4, p.e0231470, (2020)
Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma., Mondello, Patrizia, Tadros Saber, Teater Matt, Fontan Lorena, Chang Aaron Y., Jain Neeraj, Yang Haopeng, Singh Shailbala, Ying Hsia-Yuan, Chu Chi-Shuen, et al. , Cancer Discov, 2020 Mar, Volume 10, Issue 3, p.440-459, (2020)
Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML., Li, Sheng, Chen Xiaowen, Wang Jiahui, Meydan Cem, Glass Jacob L., Shih Alan H., Delwel Ruud, Levine Ross L., Mason Christopher E., and Melnick Ari M. , Cancer Discov, 2020 Dec, Volume 10, Issue 12, p.1934-1949, (2020)
Targeted detection and quantitation of histone modifications from 1,000 cells., Abshiru, Nebiyu A., Sikora Jacek W., Camarillo Jeannie M., Morris Juliette A., Compton Philip D., Lee Tak, Neelamraju Yaseswini, Haddox Samuel, Sheridan Caroline, Carroll Martin, et al. , PLoS One, 2020, Volume 15, Issue 10, p.e0240829, (2020)
TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate., Venturutti, Leandro, Teater Matt, Zhai Andrew, Chadburn Amy, Babiker Leena, Kim Daleum, Béguelin Wendy, Lee Tak C., Kim Youngjun, Chin Christopher R., et al. , Cell, 2020 Jul 23, Volume 182, Issue 2, p.297-316.e27, (2020)
The therapeutic landscape for cells engineered with chimeric antigen receptors., MacKay, Matthew, Afshinnekoo Ebrahim, Rub Jonathan, Hassan Ciaran, Khunte Mihir, Baskaran Nithyashri, Owens Bryan, Liu Lauren, Roboz Gail J., Guzman Monica L., et al. , Nat Biotechnol, 2020 Feb, Volume 38, Issue 2, p.233-244, (2020)
Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage., Chu, Chi-Shuen, Hellmuth Johannes C., Singh Rajat, Ying Hsia-Yuan, Skrabanek Lucy, Teater Matthew R., Doane Ashley S., Elemento Olivier, Melnick Ari M., and Roeder Robert G. , Mol Cell, 2020 Dec 03, Volume 80, Issue 5, p.845-861.e10, (2020)
2019
BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress., Fernando, Tharu M., Marullo Rossella, Gresely Benet Pera, Phillip Jude M., Yang Shao Ning, Lundell-Smith Geoffrey, Torregroza Ingrid, Ahn Haelee, Evans Todd, Gyorffy Balazs, et al. , Cancer Discov, 2019 May, Volume 9, Issue 5, p.662-679, (2019)
Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL., Pastore, Alessandro, Gaiti Federico, Lu Sydney X., Brand Ryan M., Kulm Scott, Chaligne Ronan, Gu Hongcang, Huang Kevin Y., Stamenova Elena K., Béguelin Wendy, et al. , Nat Commun, 2019 Apr 23, Volume 10, Issue 1, p.1874, (2019)
Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization., Gomes, Ana P., Ilter Didem, Low Vivien, Rosenzweig Adam, Shen Zih-Jie, Schild Tanya, Rivas Martín A., Er Ekrem E., McNally Dylan R., Mutvei Anders P., et al. , Cancer Cell, 2019 Oct 14, Volume 36, Issue 4, p.402-417.e13, (2019)
Emerging epigenetic-modulating therapies in lymphoma., Sermer, David, Pasqualucci Laura, Wendel Hans-Guido, Melnick Ari, and Younes Anas , Nat Rev Clin Oncol, 2019 Aug, Volume 16, Issue 8, p.494-507, (2019)
Germinal center-derived lymphomas: The darkest side of humoral immunity., Mlynarczyk, Coraline, Fontan Lorena, and Melnick Ari , Immunol Rev, 2019 Mar, Volume 288, Issue 1, p.214-239, (2019)
Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response., Agirre, Xabier, Meydan Cem, Jiang Yanwen, Garate Leire, Doane Ashley S., Li Zhuoning, Verma Akanksha, Paiva Bruno, Martín-Subero José I., Elemento Olivier, et al. , Nat Commun, 2019 Feb 18, Volume 10, Issue 1, p.821, (2019)
Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition., Ennishi, Daisuke, Takata Katsuyoshi, Béguelin Wendy, Duns Gerben, Mottok Anja, Farinha Pedro, Bashashati Ali, Saberi Saeed, Boyle Merrill, Meissner Barbara, et al. , Cancer Discov, 2019 Apr, Volume 9, Issue 4, p.546-563, (2019)
MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition., Lu, Xiangdong, Chu Chi-Shuen, Fang Terry, Rayon-Estrada Violeta, Fang Fang, Patke Alina, Qian Ye, Clarke Stephen H., Melnick Ari M., Zhang Yi, et al. , Cell Rep, 2019 Jul 09, Volume 28, Issue 2, p.472-485.e5, (2019)
The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight., Garrett-Bakelman, Francine E., Darshi Manjula, Green Stefan J., Gur Ruben C., Lin Ling, Macias Brandon R., McKenna Miles J., Meydan Cem, Mishra Tejaswini, Nasrini Jad, et al. , Science, 2019 Apr 12, Volume 364, Issue 6436, (2019)
Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis., Li, Meng, Chiang Ying-Ling, Lyssiotis Costas A., Teater Matthew R., Hong Jun Young, Shen Hao, Wang Ling, Hu Jing, Jing Hui, Chen Zhengming, et al. , Cancer Cell, 2019 Jun 10, Volume 35, Issue 6, p.916-931.e9, (2019)
PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomas., Pascual, Marien, Mena-Varas Maria, Robles Eloy Francisco, Garcia-Barchino Maria-Jose, Panizo Carlos, Hervas-Stubbs Sandra, Alignani Diego, Sagardoy Ainara, Martinez-Ferrandis Jose Ignacio, Bunting Karen L., et al. , Blood, 2019 May 30, Volume 133, Issue 22, p.2401-2412, (2019)