Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition., Ennishi, Daisuke, Takata Katsuyoshi, Béguelin Wendy, Duns Gerben, Mottok Anja, Farinha Pedro, Bashashati Ali, Saberi Saeed, Boyle Merrill, Meissner Barbara, et al. , Cancer Discov, 2019 Apr, Volume 9, Issue 4, p.546-563, (2019)

MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition., Lu, Xiangdong, Chu Chi-Shuen, Fang Terry, Rayon-Estrada Violeta, Fang Fang, Patke Alina, Qian Ye, Clarke Stephen H., Melnick Ari M., Zhang Yi, et al. , Cell Rep, 2019 Jul 09, Volume 28, Issue 2, p.472-485.e5, (2019)

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight., Garrett-Bakelman, Francine E., Darshi Manjula, Green Stefan J., Gur Ruben C., Lin Ling, Macias Brandon R., McKenna Miles J., Meydan Cem, Mishra Tejaswini, Nasrini Jad, et al. , Science, 2019 Apr 12, Volume 364, Issue 6436, (2019)

Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis., Li, Meng, Chiang Ying-Ling, Lyssiotis Costas A., Teater Matthew R., Hong Jun Young, Shen Hao, Wang Ling, Hu Jing, Jing Hui, Chen Zhengming, et al. , Cancer Cell, 2019 Jun 10, Volume 35, Issue 6, p.916-931.e9, (2019)

Rational Targeting of Cooperating Layers of the Epigenome Yields Enhanced Therapeutic Efficacy against AML., Duy, Cihangir, Teater Matt, Garrett-Bakelman Francine E., Lee Tak C., Meydan Cem, Glass Jacob L., Li Meng, Hellmuth Johannes C., Mohammad Helai P., Smitheman Kimberly N., et al. , Cancer Discov, 2019 Jul, Volume 9, Issue 7, p.872-889, (2019)

Role of chromosomal architecture in germinal center B cells and lymphomagenesis., Rivas, Martín A., and Melnick Ari M. , Curr Opin Hematol, 2019 Jul, Volume 26, Issue 4, p.294-302, (2019)

Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease., Paz, Katelyn, Flynn Ryan, Du Jing, Qi Jun, Luznik Leo, Maillard Ivan, MacDonald Kelli P., Hill Geoffrey R., Serody Jonathan S., Murphy William J., et al. , Blood, 2019 Jan 03, Volume 133, Issue 1, p.94-99, (2019)

Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs., Noh, Kyung-Min, Wang Haibo, Kim Hyunjae R., Wenderski Wendy, Fang Fang, Li Charles H., Dewell Scott, Hughes Stephen H., Melnick Ari M., Patel Dinshaw J., et al. , Mol Cell, 2018 Feb 01, Volume 69, Issue 3, p.533, (2018)

How Biophysical Forces Regulate Human B Cell Lymphomas., Apoorva, F, Loiben Alexander M., Shah Shivem B., Purwada Alberto, Fontan Lorena, Goldstein Rebecca, Kirby Brian J., Melnick Ari M., Cosgrove Benjamin D., and Singh Ankur , Cell Rep, 2018 Apr 10, Volume 23, Issue 2, p.499-511, (2018)

PRMT5 interacts with the BCL6 oncoprotein and is required for germinal center formation and lymphoma cell survival., Lu, Xiaoqing, Fernando Tharu M., Lossos Chen, Yusufova Nevin, Liu Fan, Fontan Lorena, Durant Matthew, Geng Huimin, Melnick Jacob, Luo Yuan, et al. , Blood, 2018 Nov 08, Volume 132, Issue 19, p.2026-2039, (2018)

TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis., Dominguez, Pilar M., Ghamlouch Hussein, Rosikiewicz Wojciech, Kumar Parveen, Béguelin Wendy, Fontan Lorena, Rivas Martín A., Pawlikowska Patrycja, Armand Marine, Mouly Enguerran, et al. , Cancer Discov, 2018 Dec, Volume 8, Issue 12, p.1632-1653, (2018)

CD99 is a therapeutic target on disease stem cells in myeloid malignancies., Chung, Stephen S., Eng William S., Hu Wenhuo, Khalaj Mona, Garrett-Bakelman Francine E., Tavakkoli Montreh, Levine Ross L., Carroll Martin, Klimek Virginia M., Melnick Ari M., et al. , Sci Transl Med, 2017 Jan 25, Volume 9, Issue 374, (2017)

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas., Jiang, Yanwen, Ortega-Molina Ana, Geng Huimin, Ying Hsia-Yuan, Hatzi Katerina, Parsa Sara, McNally Dylan, Wang Ling, Doane Ashley S., Agirre Xabier, et al. , Cancer Discov, 2017 Jan, Volume 7, Issue 1, p.38-53, (2017)

The Expanding Role of the BCL6 Oncoprotein as a Cancer Therapeutic Target., Cardenas, Mariano G., Oswald Erin, Yu Wenbo, Xue Fengtian, MacKerell Alexander D., and Melnick Ari M. , Clin Cancer Res, 2017 Feb 15, Volume 23, Issue 4, p.885-893, (2017)

EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop., Béguelin, Wendy, Rivas Martín A., Fernández María T. Calvo, Teater Matt, Purwada Alberto, Redmond David, Shen Hao, Challman Matt F., Elemento Olivier, Singh Ankur, et al. , Nat Commun, 2017 Oct 12, Volume 8, Issue 1, p.877, (2017)

Genetic and epigenetic inactivation of controls mTORC1 and response to EZH2 inhibition in follicular lymphoma., Oricchio, Elisa, Katanayeva Natalya, Donaldson Maria Christine, Sungalee Stephanie, Pasion Joyce P., Béguelin Wendy, Battistello Elena, Sanghvi Viraj R., Jiang Man, Jiang Yanwen, et al. , Sci Transl Med, 2017 Jun 28, Volume 9, Issue 396, (2017)

A clinical measure of DNA methylation predicts outcome in de novo acute myeloid leukemia., Luskin, Marlise R., Gimotty Phyllis A., Smith Catherine, Loren Alison W., Figueroa Maria E., Harrison Jenna, Sun Zhuoxin, Tallman Martin S., Paietta Elisabeth M., Litzow Mark R., et al. , JCI Insight, 2016 Jun 16, Volume 1, Issue 9, (2016)

Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia., Li, Sheng, Garrett-Bakelman Francine E., Chung Stephen S., Sanders Mathijs A., Hricik Todd, Rapaport Franck, Patel Jay, Dillon Richard, Vijay Priyanka, Brown Anna L., et al. , Nat Med, 2016 Jul, Volume 22, Issue 7, p.792-9, (2016)

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling., Guryanova, Olga A., Shank Kaitlyn, Spitzer Barbara, Luciani Luisa, Koche Richard P., Garrett-Bakelman Francine E., Ganzel Chezi, Durham Benjamin H., Mohanty Abhinita, Hoermann Gregor, et al. , Nat Med, 2016 Dec, Volume 22, Issue 12, p.1488-1495, (2016)

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis., Béguelin, Wendy, Teater Matt, Gearhart Micah D., Fernández María Teresa Cal, Goldstein Rebecca L., Cardenas Mariano G., Hatzi Katerina, Rosen Monica, Shen Hao, Corcoran Connie M., et al. , Cancer Cell, 2016 Aug 08, Volume 30, Issue 2, p.197-213, (2016)

A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations., Han, Dali, Lu Xingyu, Shih Alan H., Nie Ji, You Qiancheng, Xu Meng Michelle, Melnick Ari M., Levine Ross L., and He Chuan , Mol Cell, 2016 Aug 18, Volume 63, Issue 4, p.711-719, (2016)

Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics., Robles, Eloy F., Mena-Varas Maria, Barrio Laura, Merino-Cortes Sara V., Balogh Péter, Du Ming-Qing, Akasaka Takashi, Parker Anton, Roa Sergio, Panizo Carlos, et al. , Nat Commun, 2016 Jun 14, Volume 7, p.11889, (2016)

The many layers of epigenetic dysfunction in B-cell lymphomas., Jiang, Yanwen, Dominguez Pilar M., and Melnick Ari M. , Curr Opin Hematol, 2016 Jul, Volume 23, Issue 4, p.377-84, (2016)

Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region., Bunting, Karen L., T Soong David, Singh Rajat, Jiang Yanwen, Béguelin Wendy, Poloway David W., Swed Brandon L., Hatzi Katerina, Reisacher William, Teater Matt, et al. , Immunity, 2016 Sep 20, Volume 45, Issue 3, p.497-512, (2016)

Mutant IDH: a targetable driver of leukemic phenotypes linking metabolism, epigenetics and transcriptional regulation., Garrett-Bakelman, Francine E., and Melnick Ari M. , Epigenomics, 2016 Jul, Volume 8, Issue 7, p.945-57, (2016)