Found 47 results
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Journal Article
MALT1 Inhibition Is Efficacious in Both Naïve and Ibrutinib-Resistant Chronic Lymphocytic Leukemia., Saba, Nakhle S., Wong Deanna H., Tanios Georges, Iyer Jessica R., Lobelle-Rich Patricia, Dadashian Eman L., Liu Delong, Fontan Lorena, Flemington Erik K., Nichols Cydney M., et al. , Cancer Res, 2017 Dec 15, Volume 77, Issue 24, p.7038-7048, (2017)
MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo., Fontan, Lorena, Yang Chenghua, Kabaleeswaran Venkataraman, Volpon Laurent, Osborne Michael J., Beltran Elena, Garcia Monica, Cerchietti Leandro, Shaknovich Rita, Yang Shao Ning, et al. , Cancer Cell, 2012 Dec 11, Volume 22, Issue 6, p.812-24, (2012)
Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma., Clozel, Thomas, Yang ShaoNing, Elstrom Rebecca L., Tam Wayne, Martin Peter, Kormaksson Matthias, Banerjee Samprit, Vasanthakumar Aparna, Culjkovic Biljana, Scott David W., et al. , Cancer Discov, 2013 Sep, Volume 3, Issue 9, p.1002-19, (2013)
methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles., Akalin, Altuna, Kormaksson Matthias, Li Sheng, Garrett-Bakelman Francine E., Figueroa Maria E., Melnick Ari, and Mason Christopher E. , Genome Biol, 2012 Oct 03, Volume 13, Issue 10, p.R87, (2012)
miR-181a negatively regulates NF-κB signaling and affects activated B-cell-like diffuse large B-cell lymphoma pathogenesis., Kozloski, Goldi A., Jiang Xiaoyu, Bhatt Shruti, Ruiz Jose, Vega Francisco, Shaknovich Rita, Melnick Ari, and Lossos Izidore S. , Blood, 2016 Jun 09, Volume 127, Issue 23, p.2856-66, (2016)
Musashi2 sustains the mixed-lineage leukemia-driven stem cell regulatory program., Park, Sun-Mi, Gönen Mithat, Vu Ly, Minuesa Gerard, Tivnan Patrick, Barlowe Trevor S., Taggart James, Lu Yuheng, Deering Raquel P., Hacohen Nir, et al. , J Clin Invest, 2015 Mar 02, Volume 125, Issue 3, p.1286-98, (2015)
ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia., Maes, Tamara, Mascaró Cristina, Tirapu Iñigo, Estiarte Angels, Ciceri Filippo, Lunardi Serena, Guibourt Nathalie, Perdones Alvaro, Lufino Michele M. P., Somervaille Tim C. P., et al. , Cancer Cell, 2018 Mar 12, Volume 33, Issue 3, p.495-511.e12, (2018)
A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo., Cerchietti, Leandro C., Yang Shao Ning, Shaknovich Rita, Hatzi Katerina, Polo Jose M., Chadburn Amy, Dowdy Steven F., and Melnick Ari , Blood, 2009 Apr 09, Volume 113, Issue 15, p.3397-405, (2009)
Pharmacoproteomics identifies combinatorial therapy targets for diffuse large B cell lymphoma., Goldstein, Rebecca L., Yang Shao Ning, Taldone Tony, Chang Betty, Gerecitano John, Elenitoba-Johnson Kojo, Shaknovich Rita, Tam Wayne, Leonard John P., Chiosis Gabriela, et al. , J Clin Invest, 2015 Nov 03, Volume 125, Issue 12, p.4559-71, (2015)
PRMT4 blocks myeloid differentiation by assembling a methyl-RUNX1-dependent repressor complex., Vu, Ly P., Perna Fabiana, Wang Lan, Voza Francesca, Figueroa Maria E., Tempst Paul, Erdjument-Bromage Hediye, Gao Rui, Chen Sisi, Paietta Elisabeth, et al. , Cell Rep, 2013 Dec 26, Volume 5, Issue 6, p.1625-38, (2013)
Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting., Schafer, Eric, Irizarry Rafael, Negi Sandeep, McIntyre Emily, Small Donald, Figueroa Maria E., Melnick Ari, and Brown Patrick , Blood, 2010 Jun 10, Volume 115, Issue 23, p.4798-809, (2010)
PTEN opposes negative selection and enables oncogenic transformation of pre-B cells., Shojaee, Seyedmehdi, Chan Lai N., Buchner Maike, Cazzaniga Valeria, Cosgun Kadriye Nehir, Geng Huimin, Qiu Yi Hua, von Minden Marcus Dühren, Ernst Thomas, Hochhaus Andreas, et al. , Nat Med, 2016 Apr, Volume 22, Issue 4, p.379-87, (2016)
RUNX1 is a key target in t(4;11) leukemias that contributes to gene activation through an AF4-MLL complex interaction., Wilkinson, Adam C., Ballabio Erica, Geng Huimin, North Phillip, Tapia Marta, Kerry Jon, Biswas Debabrata, Roeder Robert G., C Allis David, Melnick Ari, et al. , Cell Rep, 2013 Jan 31, Volume 3, Issue 1, p.116-27, (2013)
SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells., Hammerich-Hille, Stephanie, Kaipparettu Benny A., Tsimelzon Anna, Creighton Chad J., Jiang Shiming, Polo Jose M., Melnick Ari, Meyer Rene, and Oesterreich Steffi , J Biol Chem, 2010 Feb 05, Volume 285, Issue 6, p.3608-3616, (2010)
Sequential transcription factor targeting for diffuse large B-cell lymphomas., Cerchietti, Leandro C., Polo Jose M., Da Silva Gustavo F., Farinha Pedro, Shaknovich Rita, Gascoyne Randy D., Dowdy Steven F., and Melnick Ari , Cancer Res, 2008 May 01, Volume 68, Issue 9, p.3361-9, (2008)
Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth., Fontan, Lorena, Qiao Qi, Hatcher John M., Casalena Gabriella, Us Ilkay, Teater Matt, Durant Matt, Du Guangyan, Xia Min, Bilchuk Natalia, et al. , J Clin Invest, 2018 Oct 01, Volume 128, Issue 10, p.4397-4412, (2018)
A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis., Sun, Xiao-Jian, Wang Zhanxin, Wang Lan, Jiang Yanwen, Kost Nils, T Soong David, Chen Wei-Yi, Tang Zhanyun, Nakadai Tomoyoshi, Elemento Olivier, et al. , Nature, 2013 Aug 01, Volume 500, Issue 7460, p.93-7, (2013)
Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies., Nayar, Utthara, Lu Pin, Goldstein Rebecca L., Vider Jelena, Ballon Gianna, Rodina Anna, Taldone Tony, Erdjument-Bromage Hediye, Chomet Max, Blasberg Ronald, et al. , Blood, 2013 Oct 17, Volume 122, Issue 16, p.2837-47, (2013)
Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas., Polo, Jose M., Juszczynski Przemyslaw, Monti Stefano, Cerchietti Leandro, Ye Kenny, Greally John M., Shipp Margaret, and Melnick Ari , Proc Natl Acad Sci U S A, 2007 Feb 27, Volume 104, Issue 9, p.3207-12, (2007)
Transcriptome sequencing reveals thousands of novel long non-coding RNAs in B cell lymphoma., Verma, Akanksha, Jiang Yanwen, Du Wei, Fairchild Lauren, Melnick Ari, and Elemento Olivier , Genome Med, 2015 Nov 01, Volume 7, p.110, (2015)
Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers., Agirre, Xabier, Castellano Giancarlo, Pascual Marien, Heath Simon, Kulis Marta, Segura Victor, Bergmann Anke, Esteve Anna, Merkel Angelika, Raineri Emanuele, et al. , Genome Res, 2015 Apr, Volume 25, Issue 4, p.478-87, (2015)
Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis., Alvarez, Hector, Opalinska Joanna, Zhou Li, Sohal Davendra, Fazzari Melissa J., Yu Yiting, Montagna Christina, Montgomery Elizabeth A., Canto Marcia, Dunbar Kerry B., et al. , PLoS Genet, 2011 Mar, Volume 7, Issue 3, p.e1001356, (2011)