Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells.
Ha, Kyungsoo, Fiskus Warren, Choi Dong Soon, Bhaskara Srividya, Cerchietti Leandro, Devaraj Santhana G. T., Shah Bhavin, Sharma Sunil, Chang Jenny C., Melnick Ari M., et al.
, Oncotarget, 2014 Jul 30, Volume 5, Issue 14, p.5637-50, (2014)
SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells.
Hammerich-Hille, Stephanie, Kaipparettu Benny A., Tsimelzon Anna, Creighton Chad J., Jiang Shiming, Polo Jose M., Melnick Ari, Meyer Rene, and Oesterreich Steffi
, J Biol Chem, 2010 Feb 05, Volume 285, Issue 6, p.3608-3616, (2010)
A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.
Han, Dali, Lu Xingyu, Shih Alan H., Nie Ji, You Qiancheng, Xu Meng Michelle, Melnick Ari M., Levine Ross L., and He Chuan
, Mol Cell, 2016 Aug 18, Volume 63, Issue 4, p.711-719, (2016)
Peptide-based covalent inhibitors of MALT1 paracaspase.
Hatcher, John M., Du Guangyan, Fontan Lorena, Us Ilkay, Qiao Qi, Chennamadhavuni Spandan, Shao Jay, Wu Hao, Melnick Ari, Gray Nathanael S., et al.
, Bioorg Med Chem Lett, 2019 Jun 01, Volume 29, Issue 11, p.1336-1339, (2019)
Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis.
Hatzi, Katerina, Geng Huimin, Doane Ashley S., Meydan Cem, LaRiviere Reed, Cardenas Mariano, Duy Cihangir, Shen Hao, Vidal Maria Nieves Cal, Baslan Timour, et al.
, Nat Immunol, 2019 Jan, Volume 20, Issue 1, p.86-96, (2019)
A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.
Hatzi, Katerina, Jiang Yanwen, Huang ChuanXin, Garrett-Bakelman Francine, Gearhart Micah D., Giannopoulou Eugenia G., Zumbo Paul, Kirouac Kevin, Bhaskara Srividya, Polo Jose M., et al.
, Cell Rep, 2013 Aug 15, Volume 4, Issue 3, p.578-88, (2013)
BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms.
Hatzi, Katerina, J Nance Philip, Kroenke Mark A., Bothwell Marcella, Haddad Elias K., Melnick Ari, and Crotty Shane
, J Exp Med, 2015 Apr 06, Volume 212, Issue 4, p.539-53, (2015)
A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF.
Hoatlin, M E., Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, et al.
, Blood, 1999 Dec 01, Volume 94, Issue 11, p.3737-47, (1999)
Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms.
Huang, ChuanXin, Hatzi Katerina, and Melnick Ari
, Nat Immunol, 2013 Apr, Volume 14, Issue 4, p.380-8, (2013)
Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation.
Huang, ChuanXin, Geng Huimin, Boss Isaac, Wang Ling, and Melnick Ari
, Blood, 2014 Feb 13, Volume 123, Issue 7, p.1012-20, (2014)
The BCL6 RD2 domain governs commitment of activated B cells to form germinal centers.
Huang, ChuanXin, Gonzalez David G., Cote Christine M., Jiang Yanwen, Hatzi Katerina, Teater Matt, Dai Kezhi, Hla Timothy, Haberman Ann M., and Melnick Ari
, Cell Rep, 2014 Sep 11, Volume 8, Issue 5, p.1497-508, (2014)
BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia.
Hurtz, Christian, Hatzi Katerina, Cerchietti Leandro, Braig Melanie, Park Eugene, Kim Yong-mi, Herzog Sebastian, Ramezani-Rad Parham, Jumaa Hassan, Müller Martin C., et al.
, J Exp Med, 2011 Oct 24, Volume 208, Issue 11, p.2163-74, (2011)
CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.
Jiang, Yanwen, Ortega-Molina Ana, Geng Huimin, Ying Hsia-Yuan, Hatzi Katerina, Parsa Sara, McNally Dylan, Wang Ling, Doane Ashley S., Agirre Xabier, et al.
, Cancer Discov, 2017 Jan, Volume 7, Issue 1, p.38-53, (2017)
VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma.
Jiang, Yanwen, Nie Kui, Redmond David, Melnick Ari M., Tam Wayne, and Elemento Olivier
, J Vis Exp, 2015 Dec 28, Issue 106, p.e53215, (2015)
The many layers of epigenetic dysfunction in B-cell lymphomas.
Jiang, Yanwen, Dominguez Pilar M., and Melnick Ari M.
, Curr Opin Hematol, 2016 Jul, Volume 23, Issue 4, p.377-84, (2016)
Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas.
Jiang, Yanwen, Redmond David, Nie Kui, Eng Ken W., Clozel Thomas, Martin Peter, Tan Leonard Hc, Melnick Ari M., Tam Wayne, and Elemento Olivier
, Genome Biol, 2014 Aug 15, Volume 15, Issue 8, p.432, (2014)
Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphoma.
Jiang, Yanwen, T Soong David, Wang Ling, Melnick Ari M., and Elemento Olivier
, PLoS One, 2012, Volume 7, Issue 7, p.e40332, (2012)
BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt.
Juszczynski, Przemyslaw, Chen Linfeng, O'Donnell Evan, Polo Jose M., Ranuncolo Stella M., Dalla-Favera Riccardo, Melnick Ari, and Shipp Margaret A.
, Blood, 2009 Dec 17, Volume 114, Issue 26, p.5315-21, (2009)