Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis., Alvarez, Hector, Opalinska Joanna, Zhou Li, Sohal Davendra, Fazzari Melissa J., Yu Yiting, Montagna Christina, Montgomery Elizabeth A., Canto Marcia, Dunbar Kerry B., et al. , PLoS Genet, 2011 Mar, Volume 7, Issue 3, p.e1001356, (2011)

BCL6 is critical for the development of a diverse primary B cell repertoire., Duy, Cihangir, J Yu Jessica, Nahar Rahul, Swaminathan Srividya, Kweon Soo-Mi, Polo Jose M., Valls Ester, Klemm Lars, Shojaee Seyedmehdi, Cerchietti Leandro, et al. , J Exp Med, 2010 Jun 07, Volume 207, Issue 6, p.1209-21, (2010)

BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy., Cerchietti, Leandro C., Hatzi Katerina, Caldas-Lopes Eloisi, Yang Shao Ning, Figueroa Maria E., Morin Ryan D., Hirst Martin, Mendez Lourdes, Shaknovich Rita, Cole Philip A., et al. , J Clin Invest, 2010 Dec 01, Volume 120, Issue 12, p.4569-82, (2010)

Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells., Polo, Jose M., Liu Susanna, Figueroa Maria Eugenia, Kulalert Warakorn, Eminli Sarah, Tan Kah Yong, Apostolou Effie, Stadtfeld Matthias, Li Yushan, Shioda Toshi, et al. , Nat Biotechnol, 2010 Aug, Volume 28, Issue 8, p.848-55, (2010)

DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma., Shaknovich, Rita, Geng Huimin, Johnson Nathalie A., Tsikitas Lucas, Cerchietti Leandro, Greally John M., Gascoyne Randy D., Elemento Olivier, and Melnick Ari , Blood, 2010 Nov 18, Volume 116, Issue 20, p.e81-9, (2010)

DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia., Figueroa, Maria E., Lugthart Sanne, Li Yushan, Erpelinck-Verschueren Claudia, Deng Xutao, Christos Paul J., Schifano Elizabeth, Booth James, van Putten Wim, Skrabanek Lucy, et al. , Cancer Cell, 2010 Jan 19, Volume 17, Issue 1, p.13-27, (2010)

DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis., Shah, Mrinal Y., Vasanthakumar Aparna, Barnes Natalie Y., Figueroa Maria E., Kamp Anna, Hendrick Christopher, Ostler Kelly R., Davis Elizabeth M., Lin Shang, Anastasi John, et al. , Cancer Res, 2010 Jul 15, Volume 70, Issue 14, p.5840-50, (2010)

Epigenetics in AML., Melnick, Ari M. , Best Pract Res Clin Haematol, 2010 Dec, Volume 23, Issue 4, p.463-8, (2010)

Expression of p21 protein predicts clinical outcome in DLBCL patients older than 60 years treated with R-CHOP but not CHOP: a prospective ECOG and Southwest Oncology Group correlative study on E4494., Winter, Jane N., Li Shuli, Aurora Vikas, Variakojis Daina, Nelson Beverly, Krajewska Maryla, Zhang Lijun, Habermann Thomas M., Fisher Richard I., Macon William R., et al. , Clin Cancer Res, 2010 Apr 15, Volume 16, Issue 8, p.2435-42, (2010)

EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis., Velichutina, Irina, Shaknovich Rita, Geng Huimin, Johnson Nathalie A., Gascoyne Randy D., Melnick Ari M., and Elemento Olivier , Blood, 2010 Dec 09, Volume 116, Issue 24, p.5247-55, (2010)

Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testis., Murphy, Mark W., Sarver Aaron L., Rice Daren, Hatzi Katerina, Ye Kenny, Melnick Ari, Heckert Leslie L., Zarkower David, and Bardwell Vivian J. , Proc Natl Acad Sci U S A, 2010 Jul 27, Volume 107, Issue 30, p.13360-5, (2010)

Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma., Leshchenko, Violetta V., Kuo Pei-Yu, Shaknovich Rita, Yang David T., Gellen Tobias, Petrich Adam, Yu Yiting, Remache Yvonne, Weniger Marc A., Rafiq Sarwish, et al. , Blood, 2010 Aug 19, Volume 116, Issue 7, p.1025-34, (2010)

HELP (HpaII tiny fragment enrichment by ligation-mediated PCR) assay for DNA methylation profiling of primary normal and malignant B lymphocytes., Shaknovich, Rita, Figueroa Maria E., and Melnick Ari , Methods Mol Biol, 2010, Volume 632, p.191-201, (2010)

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation., Figueroa, Maria E., Abdel-Wahab Omar, Lu Chao, Ward Patrick S., Patel Jay, Shih Alan, Li Yushan, Bhagwat Neha, Vasanthakumar Aparna, Fernandez Hugo F., et al. , Cancer Cell, 2010 Dec 14, Volume 18, Issue 6, p.553-67, (2010)

NCI first International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the committee on the biological considerations of hematological relapse following allogeneic stem c, Cairo, Mitchell S., Jordan Craig T., Maley Carlo C., Chao Clifford, Melnick Ari, Armstrong Scott A., Shlomchik Warren, Molldrem Jeff, Ferrone Soldano, Mackall Crystal, et al. , Biol Blood Marrow Transplant, 2010 Jun, Volume 16, Issue 6, p.709-28, (2010)

Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting., Schafer, Eric, Irizarry Rafael, Negi Sandeep, McIntyre Emily, Small Donald, Figueroa Maria E., Melnick Ari, and Brown Patrick , Blood, 2010 Jun 10, Volume 115, Issue 23, p.4798-809, (2010)

Response to second-line therapy defines the potential for cure in patients with recurrent diffuse large B-cell lymphoma: implications for the development of novel therapeutic strategies., Elstrom, Rebecca L., Martin Peter, Ostrow Katya, Barrientos Jacqueline, Chadburn Amy, Furman Richard, Ruan Jia, Shore Tsiporah, Schuster Michael, Cerchietti Leandro, et al. , Clin Lymphoma Myeloma Leuk, 2010 Jun, Volume 10, Issue 3, p.192-6, (2010)

SAFB1 mediates repression of immune regulators and apoptotic genes in breast cancer cells., Hammerich-Hille, Stephanie, Kaipparettu Benny A., Tsimelzon Anna, Creighton Chad J., Jiang Shiming, Polo Jose M., Melnick Ari, Meyer Rene, and Oesterreich Steffi , J Biol Chem, 2010 Feb 05, Volume 285, Issue 6, p.3608-3616, (2010)

A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo., Cerchietti, Leandro C., Ghetu Alexandru F., Zhu Xiao, Da Silva Gustavo F., Zhong Shijun, Matthews Marilyn, Bunting Karen L., Polo Jose M., Farès Christophe, Arrowsmith Cheryl H., et al. , Cancer Cell, 2010 Apr 13, Volume 17, Issue 4, p.400-11, (2010)

BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt., Juszczynski, Przemyslaw, Chen Linfeng, O'Donnell Evan, Polo Jose M., Ranuncolo Stella M., Dalla-Favera Riccardo, Melnick Ari, and Shipp Margaret A. , Blood, 2009 Dec 17, Volume 114, Issue 26, p.5315-21, (2009)

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL., Ci, Weimin, Polo Jose M., Cerchietti Leandro, Shaknovich Rita, Wang Ling, Yang Shao Ning, Ye Kenny, Farinha Pedro, Horsman Douglas E., Gascoyne Randy D., et al. , Blood, 2009 May 28, Volume 113, Issue 22, p.5536-48, (2009)

Genome-wide determination of DNA methylation by Hpa II tiny fragment enrichment by ligation-mediated PCR (HELP) for the study of acute leukemias., Figueroa, Maria E., Melnick Ari, and Greally John M. , Methods Mol Biol, 2009, Volume 538, p.395-407, (2009)

Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features., Figueroa, Maria E., Wouters Bas J., Skrabanek Lucy, Glass Jacob, Li Yushan, Erpelinck-Verschueren Claudia A. J., Langerak Anton W., Löwenberg Bob, Fazzari Melissa, Greally John M., et al. , Blood, 2009 Mar 19, Volume 113, Issue 12, p.2795-804, (2009)

High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers., Oda, Mayumi, Glass Jacob L., Thompson Reid F., Mo Yongkai, Olivier Emmanuel N., Figueroa Maria E., Selzer Rebecca R., Richmond Todd A., Zhang Xinmin, Dannenberg Luke, et al. , Nucleic Acids Res, 2009 Jul, Volume 37, Issue 12, p.3829-39, (2009)

Hsp90 inhibitor PU-H71, a multimodal inhibitor of malignancy, induces complete responses in triple-negative breast cancer models., Caldas-Lopes, Eloisi, Cerchietti Leandro, Ahn James H., Clement Cristina C., Robles Ana I., Rodina Anna, Moulick Kamalika, Taldone Tony, Gozman Alexander, Guo Yunke, et al. , Proc Natl Acad Sci U S A, 2009 May 19, Volume 106, Issue 20, p.8368-73, (2009)